Pseudomonas aeruginosa PAO1, PA1778 (cobA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1778
Name
cobA
Replicon chromosome
Genomic location 1922295 - 1923032 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250469.1
GI 15596975
Affymetrix PA1778_cobA_at
Entrez 877770
GenBank AAG05167.1
INSDC AAG05167.1
NCBI Locus Tag PA1778
protein_id(GenBank) gb|AAG05167.1|AE004603_7|gnl|PseudoCAP|PA1778
TIGR NTL03PA01779
UniParc UPI00000C5491
UniProtKB Acc Q9I2W4
UniProtKB ID SUMT_PSEAE
UniRef100 UniRef100_Q9I2W4
UniRef50 UniRef50_Q9I2W4
UniRef90 UniRef90_Q9I2W4

Product

Feature Type CDS
Coding Frame 1
Product Name
uroporphyrin-III C-methyltransferase
Product Name Confidence: Class 2
Synonyms S-adenosyl-L-methionine:uroporphyrinogen III
Evidence for Translation
Charge (pH 7) 0.81
Kyte-Doolittle Hydrophobicity Value 0.091
Molecular Weight (kDa) 25.9
Isoelectric Point (pI) 7.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 535 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003617 (491 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1778
Search term: cobA

Human Homologs

References

Cloning, sequencing, and expression of the uroporphyrinogen III methyltransferase cobA gene of Propionibacterium freudenreichii (shermanii).
Sattler I, Roessner CA, Stolowich NJ, Hardin SH, Harris-Haller LW, Yokubaitis NT, Murooka Y, Hashimoto Y, Scott AI
J Bacteriol 1995 Mar;177(6):1564-9
PubMed ID: 7883713