Pseudomonas aeruginosa PAO1, PA1985 (pqqA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1985
Name
pqqA
Replicon chromosome
Genomic location 2171865 - 2171936 (+ strand)

Cross-References

RefSeq NP_250675.1
GI 15597181
Affymetrix PA1985_pqqA_at
DNASU PaCD00006889
Entrez 880480
GenBank AAG05373.1
INSDC AAG05373.1
NCBI Locus Tag PA1985
protein_id(GenBank) gb|AAG05373.1|AE004625_3|gnl|PseudoCAP|PA1985
TIGR NTL03PA01985
UniParc UPI00000D425D
UniProtKB Acc Q9ZAA0
UniProtKB ID PQQA_PSEAE
UniRef100 UniRef100_A6V6I4
UniRef50 UniRef50_A6V6I4
UniRef90 UniRef90_A6V6I4

Product

Feature Type CDS
Coding Frame 1
Product Name
pyrroloquinoline quinone biosynthesis protein A
Product Name Confidence: Class 2
Synonyms coenzyme PQQ synthesis protein A
Evidence for Translation
Charge (pH 7) 0.98
Kyte-Doolittle Hydrophobicity Value -0.122
Molecular Weight (kDa) 2.8
Isoelectric Point (pI) 9.29

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 12 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003448 (330 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1985
Search term: pqqA

Human Homologs

References

A 24-amino-acid polypeptide is essential for the biosynthesis of the coenzyme pyrrolo-quinoline-quinone.
Goosen N, Huinen RG, van de Putte P
J Bacteriol 1992 Feb;174(4):1426-7
PubMed ID: 1310505
Synthesis of pyrroloquinoline quinone in vivo and in vitro and detection of an intermediate in the biosynthetic pathway.
Velterop JS, Sellink E, Meulenberg JJ, David S, Bulder I, Postma PW
J Bacteriol 1995 Sep;177(17):5088-98
PubMed ID: 7665488
Tn5-directed cloning of pqq genes from Pseudomonas fluorescens CHA0: mutational inactivation of the genes results in overproduction of the antibiotic pyoluteorin.
Schnider U, Keel C, Voisard C, Défago G, Haas D
Appl Environ Microbiol 1995 Nov;61(11):3856-64
PubMed ID: 8526497