Pseudomonas aeruginosa PAO1, PA2370 (hsiH3)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2370
Name
hsiH3
Replicon chromosome
Genomic location 2619695 - 2620711 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251060.1
GI 15597566
Affymetrix PA2370_at
DNASU PaCD00007035
Entrez 883136
GenBank AAG05758.1
INSDC AAG05758.1
NCBI Locus Tag PA2370
protein_id(GenBank) gb|AAG05758.1|AE004663_4|gnl|PseudoCAP|PA2370
TIGR NTL03PA02370
UniParc UPI00000C5696
UniProtKB Acc Q9I1A9
UniProtKB ID Q9I1A9_PSEAE
UniRef100 UniRef100_Q9I1A9
UniRef50 UniRef50_G8QBH4
UniRef90 UniRef90_W0YSB8

Product

Feature Type CDS
Coding Frame 1
Product Name
HsiH3
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 13.42
Kyte-Doolittle Hydrophobicity Value -0.220
Molecular Weight (kDa) 37.0
Isoelectric Point (pI) 11.28

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category Hcp secretion island-3 encoded type VI secretion system (H3-T6SS)
Evidence ECO:0000317
genomic context evidence used in manual assertion
Host Organism Caenorhabditis elegans
Notes
Infection model Caenorhabditis elegans slow killing assay. H3-T6SS rendered inactive via clpV3 deletion.
Reference 24204589

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 99 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000088 (1157 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2370
Search term: hsiH3
Search term: HsiH3

Human Homologs

References

A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.
Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordoñez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ
Science 2006 Jun 9;312(5779):1526-30
PubMed ID: 16763151
Divergent control of two type VI secretion systems by RpoN in Pseudomonas aeruginosa.
Sana TG, Soscia C, Tonglet CM, Garvis S, Bleves S
PLoS One 2013;8(10):e76030
PubMed ID: 24204589