Pseudomonas aeruginosa PAO1, PA2863 (lipH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2863
Name
lipH
Synonym: lif
Replicon chromosome
Genomic location 3215423 - 3216289 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_251553.1
GI 15598059
Affymetrix PA2863_lipH_at
DNASU PaCD00007249
Entrez 882663
GenBank AAG06251.1
INSDC AAG06251.1
NCBI Locus Tag PA2863
protein_id(GenBank) gb|AAG06251.1|AE004712_11|gnl|PseudoCAP|PA2863
TIGR NTL03PA02863
UniParc UPI000012E696
UniProtKB Acc Q01725
UniProtKB ID LIFO_PSEAE
UniRef100 UniRef100_Q01725
UniRef50 UniRef50_Q01725
UniRef90 UniRef90_Q01725

Product

Feature Type CDS
Coding Frame 1
Product Name
lipase modulator protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -6.74
Kyte-Doolittle Hydrophobicity Value -0.538
Molecular Weight (kDa) 32.4
Isoelectric Point (pI) 4.86

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 1
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5OVM CHAPERONE 08/29/17 Solution structure of lipase binding domain LID1 of foldase from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) NOT SOLUTION NMR 100.0
6GSF CHAPERONE 06/14/18 Solution structure of lipase binding domain LID1 of foldase from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 NOT SOLUTION NMR 98.8

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 27 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002706 (326 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2863
Search term: lipH

Human Homologs

References

Bacterial lipases.
Jaeger KE, Ransac S, Dijkstra BW, Colson C, van Heuvel M, Misset O
FEMS Microbiol Rev 1994 Sep;15(1):29-63
PubMed ID: 7946464
Purification, molecular cloning, and expression of lipase from Pseudomonas aeruginosa.
Chihara-Siomi M, Yoshikawa K, Oshima-Hirayama N, Yamamoto K, Sogabe Y, Nakatani T, Nishioka T, Oda J
Arch Biochem Biophys 1992 Aug 1;296(2):505-13
PubMed ID: 1632642