Pseudomonas aeruginosa PAO1, PA2924 (hisQ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2924
Name
hisQ
Replicon chromosome
Genomic location 3279479 - 3280168 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251614.1
GI 15598120
Affymetrix PA2924_hisQ_at
DNASU PaCD00007274
Entrez 882696
GenBank AAG06312.1
INSDC AAG06312.1
NCBI Locus Tag PA2924
protein_id(GenBank) gb|AAG06312.1|AE004718_9|gnl|PseudoCAP|PA2924
TIGR NTL03PA02924
UniParc UPI00000C5887
UniProtKB Acc Q9HZS3
UniProtKB ID Q9HZS3_PSEAE
UniRef100 UniRef100_W0YSU0
UniRef50 UniRef50_Q6D2P6
UniRef90 UniRef90_Q02P86

Product

Feature Type CDS
Coding Frame 1
Product Name
histidine transport system permease HisQ
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 9.16
Kyte-Doolittle Hydrophobicity Value 0.720
Molecular Weight (kDa) 24.5
Isoelectric Point (pI) 10.49

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 446 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002653 (433 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2924
Search term: hisQ

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Reconstitution of periplasmic transport in inside-out membrane vesicles. Energization by ATP.
Ames GF, Nikaido K, Groarke J, Petithory J
J Biol Chem 1989 Mar 5;264(7):3998-4002
PubMed ID: 2645283
Topology of the hydrophobic membrane-bound components of the histidine periplasmic permease. Comparison with other members of the family.
Kerppola RE, Ames GF
J Biol Chem 1992 Feb 5;267(4):2329-36
PubMed ID: 1733937