Pseudomonas aeruginosa PAO1, PA3406 (hasD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3406
Name
hasD
Replicon chromosome
Genomic location 3811938 - 3813740 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq NP_252096.1
GI 15598602
Affymetrix PA3406_hasD_at
Entrez 878849
GenBank AAG06794.1
INSDC AAG06794.1
NCBI Locus Tag PA3406
protein_id(GenBank) gb|AAG06794.1|AE004761_10|gnl|PseudoCAP|PA3406
TIGR NTL03PA03406
UniParc UPI00000C59F5
UniProtKB Acc Q9HYJ8
UniProtKB ID Q9HYJ8_PSEAE
UniRef100 UniRef100_Q9HYJ8
UniRef50 UniRef50_Q03024
UniRef90 UniRef90_Q9HYJ8

Product

Feature Type CDS
Coding Frame 1
Product Name
transport protein HasD
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 13.42
Kyte-Doolittle Hydrophobicity Value 0.325
Molecular Weight (kDa) 63.5
Isoelectric Point (pI) 10.55

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001198 (779 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3406
Search term: hasD

Human Homologs

Ensembl 110, assembly GRCh38.p14
transporter 1, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43]
E-value: 3.7e-33
Percent Identity: 35.8

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Secretion of the Serratia marcescens HasA protein by an ABC transporter.
Létoffé S, Ghigo JM, Wandersman C
J Bacteriol 1994 Sep;176(17):5372-7
PubMed ID: 8071214
Lipase secretion by bacterial hybrid ATP-binding cassette exporters: molecular recognition of the LipBCD, PrtDEF, and HasDEF exporters.
Akatsuka H, Binet R, Kawai E, Wandersman C, Omori K
J Bacteriol 1997 Aug;179(15):4754-60
PubMed ID: 9244262