Pseudomonas aeruginosa PAO1, PA3816 (cysE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3816
Name
cysE
Replicon chromosome
Genomic location 4272801 - 4273577 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252505.1
GI 15599011
Affymetrix PA3816_cysE_at
Entrez 879926
GenBank AAG07203.1
INSDC AAG07203.1
NCBI Locus Tag PA3816
protein_id(GenBank) gb|AAG07203.1|AE004799_9|gnl|PseudoCAP|PA3816
TIGR NTL03PA03816
UniParc UPI00000C5B24
UniProtKB Acc Q9HXI6
UniProtKB ID Q9HXI6_PSEAE
UniRef100 UniRef100_W0YUG0
UniRef50 UniRef50_P23145
UniRef90 UniRef90_A0A024HBZ0

Product

Feature Type CDS
Coding Frame 1
Product Name
O-acetylserine synthase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.17
Kyte-Doolittle Hydrophobicity Value -0.150
Molecular Weight (kDa) 27.9
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 573 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001850 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3816
Search term: cysE

Human Homologs

References

Clustering and co-transcription of the Bacillus subtilis genes encoding the aminoacyl-tRNA synthetases specific for glutamate and for cysteine and the first enzyme for cysteine biosynthesis.
Gagnon Y, Breton R, Putzer H, Pelchat M, Grunberg-Manago M, Lapointe J
J Biol Chem 1994 Mar 11;269(10):7473-82
PubMed ID: 7510287
Assembly of iron-sulfur clusters. Identification of an iscSUA-hscBA-fdx gene cluster from Azotobacter vinelandii.
Zheng L, Cash VL, Flint DH, Dean DR
J Biol Chem 1998 May 22;273(21):13264-72
PubMed ID: 9582371