Pseudomonas aeruginosa PAO1, PA4355 (pyeM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4355
Name
pyeM
Synonym: araJ
Replicon chromosome
Genomic location 4882404 - 4883570 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253045.1
GI 15599551
Affymetrix PA4355_at
Entrez 881442
GenBank AAG07743.1
INSDC AAG07743.1
NCBI Locus Tag PA4355
protein_id(GenBank) gb|AAG07743.1|AE004851_11|gnl|PseudoCAP|PA4355
TIGR NTL03PA04356
UniParc UPI00000C5CDA
UniProtKB Acc Q9HW46
UniProtKB ID Q9HW46_PSEAE
UniRef100 UniRef100_W0YW85
UniRef50 UniRef50_G0G0Q7
UniRef90 UniRef90_V6AKV8

Product

Feature Type CDS
Coding Frame 1
Product Name
PyeM
Product Name Confidence: Class 2
Synonyms Pseudomonas yellow enzyme MFS transporter
probable MFS transporter
Evidence for Translation
Charge (pH 7) 5.65
Kyte-Doolittle Hydrophobicity Value 1.005
Molecular Weight (kDa) 39.9
Isoelectric Point (pI) 10.05

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 420 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003948 (530 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4355
Search term: pyeM
Search term: PyeM

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa.
Mac Aogáin M, Mooij MJ, McCarthy RR, Plower E, Wang YP, Tian ZX, Dobson A, Morrissey J, Adams C, O'Gara F
Microbiology (Reading) 2012 Oct;158(Pt 10):2598-2609
PubMed ID: 22820840