Pseudomonas aeruginosa PAO1, PA4751 (ftsH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4751
Name
ftsH
Synonym: tolZ
Synonym: hflB
Synonym: mrsC
Replicon chromosome
Genomic location 5335782 - 5337701 (- strand)

Cross-References

RefSeq NP_253439.1
GI 15599945
Affymetrix PA4751_ftsH_at
Entrez 881716
GenBank AAG08137.1
INSDC AAG08137.1
NCBI Locus Tag PA4751
protein_id(GenBank) gb|AAG08137.1|AE004888_12|gnl|PseudoCAP|PA4751
TIGR NTL03PA04752
UniParc UPI00000C5DF2
UniProtKB Acc Q9HV48
UniProtKB ID Q9HV48_PSEAE
UniRef100 UniRef100_A6VCK8
UniRef50 UniRef50_B3DY14
UniRef90 UniRef90_C3K266

Product

Feature Type CDS
Coding Frame 1
Product Name
cell division protein FtsH
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected using LC-MS/MS (69.95 kDa, PMID:21751344)
Charge (pH 7) -8.66
Kyte-Doolittle Hydrophobicity Value -0.251
Molecular Weight (kDa) 70.0
Isoelectric Point (pI) 5.62

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Vesicle Class 1
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 667 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004396 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4751
Search term: ftsH

Human Homologs

Ensembl 110, assembly GRCh38.p14
AFG3 like matrix AAA peptidase subunit 2 [Source:HGNC Symbol;Acc:HGNC:315]
E-value: 1.3e-124
Percent Identity: 48.3
Ensembl 110, assembly GRCh38.p14
AFG3 like matrix AAA peptidase subunit 2 [Source:HGNC Symbol;Acc:HGNC:315]
E-value: 1.3e-124
Percent Identity: 48.3

References

The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression.
Tomoyasu T, Yuki T, Morimura S, Mori H, Yamanaka K, Niki H, Hiraga S, Ogura T
J Bacteriol 1993 Mar;175(5):1344-51
PubMed ID: 8444796
Escherichia coli FtsH is a membrane-bound, ATP-dependent protease which degrades the heat-shock transcription factor sigma 32.
Tomoyasu T, Gamer J, Bukau B, Kanemori M, Mori H, Rutman AJ, Oppenheim AB, Yura T, Yamanaka K, Niki H
EMBO J 1995 Jun 1;14(11):2551-60
PubMed ID: 7781608
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344