Pseudomonas aeruginosa PAO1, PA4992

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4992
Name
Replicon chromosome
Genomic location 5607668 - 5608480 (+ strand)

Cross-References

RefSeq NP_253679.1
GI 15600185
Affymetrix PA4992_at
DNASU PaCD00008156
Entrez 880167
GenBank AAG08377.1
INSDC AAG08377.1
NCBI Locus Tag PA4992
protein_id(GenBank) gb|AAG08377.1|AE004912_3|gnl|PseudoCAP|PA4992
TIGR NTL03PA04993
UniParc UPI00000C5EB5
UniProtKB Acc Q9HUH3
UniProtKB ID Q9HUH3_PSEAE
UniRef100 UniRef100_Q9HUH3
UniRef50 UniRef50_Q9HUH3
UniRef90 UniRef90_Q9HUH3

Product

Feature Type CDS
Coding Frame 1
Product Name
putative aldo-keto reductase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.89
Kyte-Doolittle Hydrophobicity Value -0.101
Molecular Weight (kDa) 29.0
Isoelectric Point (pI) 6.43

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4EXA OXIDOREDUCTASE 04/30/12 Crystal structure of the PA4992, the putative aldo-keto reductase from Pseudomona aeruginosa Pseudomonas aeruginosa PAO1 2.8 X-RAY DIFFRACTION 100.0
4EXB OXIDOREDUCTASE 04/30/12 Putative aldo-keto reductase from Pseudomona aeruginosa Pseudomonas aeruginosa 2.75 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 501 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004602 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4992

Human Homologs

References

The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.
Moynie L, Schnell R, McMahon SA, Sandalova T, Boulkerou WA, Schmidberger JW, Alphey M, Cukier C, Duthie F, Kopec J, Liu H, Jacewicz A, Hunter WN, Naismith JH, Schneider G
Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Jan 1;69(Pt 1):25-34
PubMed ID: 23295481