Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA5117
|
Name |
typA
Synonym: bipA |
Replicon | chromosome |
Genomic location | 5762659 - 5764611 (- strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Comment | Translation confirmed using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer. Coordinates verified using RT-PCR (PMID:24291602). |
RefSeq | NP_253804.1 |
GI | 15600310 |
Affymetrix | PA5117_typA_at |
Entrez | 879601 |
GenBank | AAG08502.1 |
INSDC | AAG08502.1 |
NCBI Locus Tag | PA5117 |
protein_id(GenBank) | gb|AAG08502.1|AE004924_7|gnl|PseudoCAP|PA5117 |
TIGR | NTL03PA05118 |
UniParc | UPI00000C5F0E |
UniProtKB Acc | Q9HU67 |
UniProtKB ID | Q9HU67_PSEAE |
UniRef100 | UniRef100_Q9HU67 |
UniRef50 | UniRef50_P0A3B2 |
UniRef90 | UniRef90_Q9HU67 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
regulatory protein TypA
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
|
Charge (pH 7) | -16.36 |
Kyte-Doolittle Hydrophobicity Value | -0.309 |
Molecular Weight (kDa) | 66.9 |
Isoelectric Point (pI) | 5.01 |
Individual Mappings | |
Additional evidence for subcellular localization |
Source 1 | |
Database | PseudoCAP |
Category | |
Evidence |
ECO:0000314
direct assay evidence used in manual assertion
|
Host Organism | Caenorhabditis elegans |
Notes | |
Infection model | C. elegans Infection model |
Reference | 23570569 |
Source 2 | |
Database | PseudoCAP |
Category | |
Evidence |
ECO:0000314
direct assay evidence used in manual assertion
|
Host Organism | Drosophila melanogaster |
Notes | |
Infection model | D. discoideum Infection model |
Reference | 23570569 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG004710 (535 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA5117
Search term: typA
Search term: regulatory protein TypA
|
Ensembl
110, assembly
GRCh38.p14
|
GTP binding elongation factor GUF1 [Source:HGNC Symbol;Acc:HGNC:25799]
E-value:
3.0e-41
Percent Identity:
28.2
|
BipA: a tyrosine-phosphorylated GTPase that mediates interactions between enteropathogenic Escherichia coli (EPEC) and epithelial cells.
Farris M, Grant A, Richardson TB, O'Connor CD
Mol Microbiol 1998 Apr;28(2):265-79
PubMed ID: 9622352
|
Tyrosine phosphorylation in Escherichia coli.
Freestone P, Trinei M, Clarke SC, Nyström T, Norris V
J Mol Biol 1998 Jun 26;279(5):1045-51
PubMed ID: 9642082
|
Protein phosphorylation in Escherichia coli L. form NC-7.
Freestone P, Grant S, Trinei M, Onoda T, Norris V
Microbiology (Reading) 1998 Dec;144 ( Pt 12):3289-3295
PubMed ID: 9884220
|
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
|
TypA is involved in virulence, antimicrobial resistance and biofilm formation in Pseudomonas aeruginosa.
Neidig A, Yeung AT, Rosay T, Tettmann B, Strempel N, Rueger M, Lesouhaitier O, Overhage J
BMC Microbiol 2013 Apr 9;13:77
PubMed ID: 23570569
|
Identification of genes involved in swarming motility using a Pseudomonas aeruginosa PAO1 mini-Tn5-lux mutant library.
Overhage J, Lewenza S, Marr AK, Hancock RE
J Bacteriol 2007 Mar;189(5):2164-9
PubMed ID: 17158671
|
LTQ-XL mass spectrometry proteome analysis expands the Pseudomonas aeruginosa AmpR regulon to include cyclic di-GMP phosphodiesterases and phosphoproteins, and identifies novel open reading frames.
Kumari H, Murugapiran SK, Balasubramanian D, Schneper L, Merighi M, Sarracino D, Lory S, Mathee K
J Proteomics 2014 Jan 16;96:328-342
PubMed ID: 24291602
|