Pseudomonas aeruginosa PAO1, PA5358 (ubiA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5358
Name
ubiA
Replicon chromosome
Genomic location 6025305 - 6026195 (+ strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_254045.1
GI 15600551
Affymetrix PA5358_ubiA_at
DNASU PaCD00008321
Entrez 880317
GenBank AAG08743.1
INSDC AAG08743.1
NCBI Locus Tag PA5358
protein_id(GenBank) gb|AAG08743.1|AE004947_13|gnl|PseudoCAP|PA5358
TIGR NTL03PA05359
UniParc UPI00000C5FC1
UniProtKB Acc Q9HTK0
UniProtKB ID UBIA_PSEAE
UniRef100 UniRef100_B7V5P9
UniRef50 UniRef50_Q12S01
UniRef90 UniRef90_B7V5P9

Product

Feature Type CDS
Coding Frame 1
Product Name
4-hydroxybenzoate-octaprenyl transferase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 3.83
Kyte-Doolittle Hydrophobicity Value 0.632
Molecular Weight (kDa) 33.0
Isoelectric Point (pI) 8.58

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 440 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004923 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5358
Search term: ubiA

Human Homologs

Ensembl 110, assembly GRCh38.p14
coenzyme Q2, polyprenyltransferase [Source:HGNC Symbol;Acc:HGNC:25223]
E-value: 1.9e-43
Percent Identity: 35.6
Ensembl 110, assembly GRCh38.p14
coenzyme Q2, polyprenyltransferase [Source:HGNC Symbol;Acc:HGNC:25223]
E-value: 1.9e-43
Percent Identity: 35.6

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Ubiquinone biosynthesis. Cloning of the genes coding for chorismate pyruvate-lyase and 4-hydroxybenzoate octaprenyl transferase from Escherichia coli.
Siebert M, Bechthold A, Melzer M, May U, Berger U, Schröder G, Schröder J, Severin K, Heide L
FEBS Lett 1992 Aug 3;307(3):347-50
PubMed ID: 1644192