Pseudomonas aeruginosa PAO1, PA5471 (armZ)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Replicon chromosome
Genomic location 6159560 - 6160699 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs


RefSeq NP_254158.1
GI 15600664
Affymetrix PA5471_at
Entrez 877632
GenBank AAG08856.1
INSDC AAG08856.1
NCBI Locus Tag PA5471
protein_id(GenBank) gb|AAG08856.1|AE004959_12|gnl|PseudoCAP|PA5471
UniParc UPI00000C6024
UniProtKB Acc Q9HT99
UniRef100 UniRef100_Q9HT99
UniRef50 UniRef50_Q39GF9
UniRef90 UniRef90_Q9HT99


Feature Type CDS
Coding Frame 1
Product Name
Product Name Confidence: Class 1
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.35
Kyte-Doolittle Hydrophobicity Value -0.062
Molecular Weight (kDa) 41.0
Isoelectric Point (pI) 6.64

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 337 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG005013 (316 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA5471
Search term: armZ
Search term: ArmZ

Human Homologs

Ensembl 97, assembly GRCh38.p12
RNA 2',3'-cyclic phosphate and 5'-OH ligase [Source:HGNC Symbol;Acc:HGNC:26935]
E-value: 8.9e-26
Percent Identity: 28.2


Role of MexZ and PA5471 in transcriptional regulation of mexXY in Pseudomonas aeruginosa.
Yamamoto M, Ueda A, Kudo M, Matsuo Y, Fukushima J, Nakae T, Kaneko T, Ishigatsubo Y
Microbiology (Reading, Engl.) 2009 Oct;155(Pt 10):3312-21
PubMed ID: 19589837
Chromosomal mechanisms of aminoglycoside resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
Islam S, Oh H, Jalal S, Karpati F, Ciofu O, Høiby N, Wretlind B
Clin. Microbiol. Infect. 2009 Jan;15(1):60-6
PubMed ID: 19154484
Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibiotic-inducible PA5471 gene product.
Morita Y, Sobel ML, Poole K
J. Bacteriol. 2006 Mar;188(5):1847-55
PubMed ID: 16484195
Genome-scale identification method applied to find cryptic aminoglycoside resistance genes in Pseudomonas aeruginosa.
Struble JM, Gill RT
PLoS ONE 2009 Nov;4(11):e6576
PubMed ID: 19907650
Translational control of the antibiotic inducibility of the PA5471 gene required for mexXY multidrug efflux gene expression in Pseudomonas aeruginosa.
Morita Y, Gilmour C, Metcalf D, Poole K
J. Bacteriol. 2009 Aug;191(15):4966-75
PubMed ID: 19465646
Fmt bypass in Pseudomonas aeruginosa causes induction of MexXY efflux pump expression.
Caughlan RE, Sriram S, Daigle DM, Woods AL, Buco J, Peterson RL, Dzink-Fox J, Walker S, Dean CR
Antimicrob. Agents Chemother. 2009 Dec;53(12):5015-21
PubMed ID: 19786597
Antibiotic inducibility of the mexXY multidrug efflux operon of Pseudomonas aeruginosa: involvement of the MexZ anti-repressor ArmZ.
Hay T, Fraud S, Lau CH, Gilmour C, Poole K
PLoS ONE 2013 ;8(2):e56858
PubMed ID: 23441219