Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA0423.1
|
Name |
AS1974
|
Replicon | chromosome |
Genomic location | 471298 - 471425 (+ strand) |
Comment | Downregulated in all drug-resistant strains compared with all drug-susceptible strains. |
Comment | Binds to Hfq with high specificity |
Comment | Overexpression of AS1974 was able to transform a MDR clinical strain to drug hypersusceptibility |
Comment | AS1974 sRNA expression is regulated by methylation in all MDR strains examined (PMID:30901580) |
A Small RNA Transforms the Multidrug Resistance of Pseudomonas aeruginosa to Drug Susceptibility.
Law COK, Huang C, Pan Q, Lee J, Hao Q, Chan TF, Lo NWS, Ang IL, Koon A, Ip M, Chan E, Lau TCK
Mol Ther Nucleic Acids 2019 Jun 7;16:218-228
PubMed ID: 30901580
|