Pseudomonas putida GB-1, PputGB1_4426

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas putida GB-1
GCF_000019125.1|latest
Locus Tag
PputGB1_4426
Name
Replicon chromosome
Genomic location 4953705 - 4954337 (- strand)

Cross-References

RefSeq YP_001670650.1
GI 167035419
Entrez 5872234
INSDC ABZ00315.1
NCBI Locus Tag PputGB1_4426
UniParc UPI0000F25651
UniProtKB Acc B0KV79
UniProtKB ID B0KV79_PSEPG
UniRef100 UniRef100_B0KV79
UniRef50 UniRef50_Q9AIU0
UniRef90 UniRef90_Q9AIU0

Product

Feature Type CDS
Coding Frame 1
Product Name
TetR family transcriptional regulator
Synonyms
Evidence for Translation
Charge (pH 7) -4.43
Kyte-Doolittle Hydrophobicity Value -0.220
Molecular Weight (kDa) 23739.0
Isoelectric Point (pI) 5.91

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2UXU TRANSCRIPTION 03/29/07 TtgR in complex with Naringenin PSEUDOMONAS PUTIDA 2.3 X-RAY DIFFRACTION 97.6
2UXI TRANSCRIPTION 03/28/07 Phloretin in complex with TtgR PSEUDOMONAS PUTIDA 2.5 X-RAY DIFFRACTION 97.6
2UXP TRANSCRIPTION 03/29/07 TtgR in complex Chloramphenicol PSEUDOMONAS PUTIDA 2.7 X-RAY DIFFRACTION 97.6
2UXO TRANSCRIPTION 03/28/07 TtgR in complex with Tetracycline PSEUDOMONAS PUTIDA 2.7 X-RAY DIFFRACTION 97.6
2XDN TRANSCRIPTION 05/04/10 Transcription factor TtgR H67A mutant PSEUDOMONAS PUTIDA 2.2 X-RAY DIFFRACTION 97.1
2UXH TRANSCRIPTION 03/28/07 TtgR in complex with Quercetin PSEUDOMONAS PUTIDA 2.4 X-RAY DIFFRACTION 97.6

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
3-(4-HYDROXYPHENYL)-1-(2,4,6-TRIHYDROXYPHENYL)PROPAN-1-ONE DB07810 DrugBank 5.1.4 Q9AIU0 HTH-type transcriptional regulator TtgR 97.6 210 7.1e-112
Quercetin DB04216 DrugBank 5.1.4 Q9AIU0 HTH-type transcriptional regulator TtgR 97.6 210 7.1e-112
Naringenin DB03467 DrugBank 5.1.4 Q9AIU0 HTH-type transcriptional regulator TtgR 97.6 210 7.1e-112

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 345 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002095 (539 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PputGB1_4426

Human Homologs

References

No references are associated with this feature.