Pseudomonas putida GB-1, PputGB1_4651

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas putida GB-1
GCF_000019125.1|latest
Locus Tag
PputGB1_4651
Name
Replicon chromosome
Genomic location 5188731 - 5189450 (- strand)

Cross-References

RefSeq YP_001670873.1
GI 167035642
Entrez 5872459
NCBI Locus Tag PputGB1_4651

Product

Feature Type CDS
Coding Frame 1
Product Name
protocatechuate 3,4-dioxygenase subunit beta
Synonyms
Evidence for Translation
Charge (pH 7) 6.79
Kyte-Doolittle Hydrophobicity Value -0.463
Molecular Weight (kDa) 26880.4
Isoelectric Point (pI) 9.11

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3PCB DIOXYGENASE 04/25/97 STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 3-HYDROXYBENZOATE Pseudomonas putida 2.19 X-RAY DIFFRACTION 97.9
3PCH DIOXYGENASE 07/01/97 STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 3-CHLORO-4-HYDROXYBENZOATE Pseudomonas putida 2.05 X-RAY DIFFRACTION 97.9
3PCC DIOXYGENASE 04/29/97 STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 4-HYDROXYBENZOATE Pseudomonas putida 1.98 X-RAY DIFFRACTION 97.9
3PCG DIOXYGENASE 04/29/97 STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH THE INHIBITOR 4-HYDROXYPHENYLACETATE Pseudomonas putida 1.96 X-RAY DIFFRACTION 97.9
3PCI DIOXYGENASE 07/02/97 STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 3-IODO-4-HYDROXYBENZOATE Pseudomonas putida 2.21 X-RAY DIFFRACTION 97.9
3PCF DIOXYGENASE 06/27/97 STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 3-FLURO-4-HYDROXYBENZOATE Pseudomonas putida 2.15 X-RAY DIFFRACTION 97.9
3PCJ DIOXYGENASE 07/18/97 STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 2-HYDROXYISONICOTINIC ACID N-OXIDE Pseudomonas putida 2.13 X-RAY DIFFRACTION 97.9
3PCN DIOXYGENASE 08/19/97 STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 3,4-DIHYDROXYPHENYLACETATE Pseudomonas putida 2.4 X-RAY DIFFRACTION 97.9
3T67 OXIDOREDUCTASE 07/28/11 Axial Ligand Swapping In Double Mutant Maintains Intradiol-cleavage Chemistry in Protocatechuate 3,4-Dioxygenase Pseudomonas putida 1.67 X-RAY DIFFRACTION 97.9

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
2-(3,4-Dihydroxyphenyl)Acetic Acid DB01702 DrugBank 5.1.4 P00437 Protocatechuate 3,4-dioxygenase beta chain 97.9 239 2.8e-141

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 129 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000151 (503 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PputGB1_4651

Human Homologs

References

No references are associated with this feature.