Pseudomonas putida S16, PPS_4266

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas putida S16
GCF_000219705.1|latest
Locus Tag
PPS_4266
Name
Replicon chromosome
Genomic location 4833496 - 4834128 (- strand)

Cross-References

RefSeq YP_004703681.1
GI 339489153
Entrez 10939884
INSDC AEJ14801.1
NCBI Locus Tag PPS_4266
UniParc UPI0002173783
UniProtKB Acc F8G4A8
UniProtKB ID F8G4A8_PSEP6
UniRef100 UniRef100_A0A099N569
UniRef50 UniRef50_Q9AIU0
UniRef90 UniRef90_Q9AIU0

Product

Feature Type CDS
Coding Frame 1
Product Name
TetR family transcriptional regulator
Synonyms
Evidence for Translation
Charge (pH 7) -3.43
Kyte-Doolittle Hydrophobicity Value -0.225
Molecular Weight (kDa) 23.8
Isoelectric Point (pI) 6.17

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2UXI TRANSCRIPTION 03/28/07 Phloretin in complex with TtgR PSEUDOMONAS PUTIDA 2.5 X-RAY DIFFRACTION 97.6
7KD8 TRANSCRIPTION 10/08/20 TtgR C137I I141W M167L F168Y mutant in complex with resveratrol Pseudomonas putida 1.71 X-RAY DIFFRACTION 95.7
2UXU TRANSCRIPTION 03/29/07 TtgR in complex with Naringenin PSEUDOMONAS PUTIDA 2.3 X-RAY DIFFRACTION 97.6
2XDN TRANSCRIPTION 05/04/10 Transcription factor TtgR H67A mutant PSEUDOMONAS PUTIDA 2.2 X-RAY DIFFRACTION 97.1
2UXH TRANSCRIPTION 03/28/07 TtgR in complex with Quercetin PSEUDOMONAS PUTIDA 2.4 X-RAY DIFFRACTION 97.6
7K1A TRANSCRIPTION 09/07/20 TtgR quadruple mutant (C137I I141W M167L F168Y) Pseudomonas putida 1.75 X-RAY DIFFRACTION 95.7
2UXP TRANSCRIPTION 03/29/07 TtgR in complex Chloramphenicol PSEUDOMONAS PUTIDA 2.7 X-RAY DIFFRACTION 97.6
7K1C TRANSCRIPTION 09/07/20 TtgR in complex with resveratrol Pseudomonas putida 1.9 X-RAY DIFFRACTION 97.6
2UXO TRANSCRIPTION 03/28/07 TtgR in complex with Tetracycline PSEUDOMONAS PUTIDA 2.7 X-RAY DIFFRACTION 97.6

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Quercetin DB04216 DrugBank 5.1.4 Q9AIU0 HTH-type transcriptional regulator TtgR 97.6 210 2.1e-111
Naringenin DB03467 DrugBank 5.1.4 Q9AIU0 HTH-type transcriptional regulator TtgR 97.6 210 2.1e-111
3-(4-HYDROXYPHENYL)-1-(2,4,6-TRIHYDROXYPHENYL)PROPAN-1-ONE DB07810 DrugBank 5.1.4 Q9AIU0 HTH-type transcriptional regulator TtgR 97.6 210 2.1e-111

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 347 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002095 (523 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PPS_4266

Human Homologs

References

No references are associated with this feature.