Pseudomonas putida BIRD-1, PPUBIRD1_4173 (ttgR)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas putida BIRD-1
GCF_000183645.1|latest |
| Locus Tag |
PPUBIRD1_4173
|
| Name |
ttgR
|
| Replicon | chromosome |
| Genomic location | 4659716 - 4660348 (- strand) |
Cross-References
| RefSeq | YP_005931957.1 |
| GI | 386013680 |
| Entrez | 12522351 |
| NCBI Locus Tag | PPUBIRD1_4173 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
TtgR
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -4.43 |
| Kyte-Doolittle Hydrophobicity Value | -0.225 |
| Molecular Weight (kDa) | 23.8 |
| Isoelectric Point (pI) | 5.91 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 7K1A | TRANSCRIPTION | 09/07/20 | TtgR quadruple mutant (C137I I141W M167L F168Y) | Pseudomonas putida | 1.75 | X-RAY DIFFRACTION | 96.7 |
| 2XDN | TRANSCRIPTION | 05/04/10 | Transcription factor TtgR H67A mutant | PSEUDOMONAS PUTIDA | 2.2 | X-RAY DIFFRACTION | 98.1 |
| 7K1C | TRANSCRIPTION | 09/07/20 | TtgR in complex with resveratrol | Pseudomonas putida | 1.9 | X-RAY DIFFRACTION | 98.6 |
| 2UXO | TRANSCRIPTION | 03/28/07 | TtgR in complex with Tetracycline | PSEUDOMONAS PUTIDA | 2.7 | X-RAY DIFFRACTION | 98.6 |
| 2UXU | TRANSCRIPTION | 03/29/07 | TtgR in complex with Naringenin | PSEUDOMONAS PUTIDA | 2.3 | X-RAY DIFFRACTION | 98.6 |
| 7KD8 | TRANSCRIPTION | 10/08/20 | TtgR C137I I141W M167L F168Y mutant in complex with resveratrol | Pseudomonas putida | 1.71 | X-RAY DIFFRACTION | 96.7 |
| 2UXP | TRANSCRIPTION | 03/29/07 | TtgR in complex Chloramphenicol | PSEUDOMONAS PUTIDA | 2.7 | X-RAY DIFFRACTION | 98.6 |
| 2UXH | TRANSCRIPTION | 03/28/07 | TtgR in complex with Quercetin | PSEUDOMONAS PUTIDA | 2.4 | X-RAY DIFFRACTION | 98.6 |
| 2UXI | TRANSCRIPTION | 03/28/07 | Phloretin in complex with TtgR | PSEUDOMONAS PUTIDA | 2.5 | X-RAY DIFFRACTION | 98.6 |
Drugs Targeting this Protein
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
| Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
| Quercetin | DB04216 | DrugBank | 5.1.4 | Q9AIU0 | HTH-type transcriptional regulator TtgR | 98.6 | 210 | 1.1e-112 |
| Naringenin | DB03467 | DrugBank | 5.1.4 | Q9AIU0 | HTH-type transcriptional regulator TtgR | 98.6 | 210 | 1.1e-112 |
| 3-(4-HYDROXYPHENYL)-1-(2,4,6-TRIHYDROXYPHENYL)PROPAN-1-ONE | DB07810 | DrugBank | 5.1.4 | Q9AIU0 | HTH-type transcriptional regulator TtgR | 98.6 | 210 | 1.1e-112 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 345 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG002095 (523 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PPUBIRD1_4173
Search term: ttgR
Search term: TtgR
|
Human Homologs
References
No references are associated with this feature.