Pseudomonas aeruginosa UCBPP-PA14, PA14_18080

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_18080
Name
Replicon	chromosome
Genomic location	1550981 - 1551619 (- strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	6 transposon mutants in orthologs

Cross-References

RefSeq	YP_789591.1
GI	116051571
Entrez	4381537
INSDC	ABJ12807.1
NCBI Locus Tag	PA14_18080
UniParc	UPI00000C5A74
UniProtKB Acc	Q02R45
UniProtKB ID	Q02R45_PSEAB
UniRef100	UniRef100_W0YTN0
UniRef50	UniRef50_B7VAK7
UniRef90	UniRef90_B7VAK7

Product

Feature Type	CDS
Coding Frame	1
Product Name	TetR family transcriptional regulator
Synonyms
Evidence for Translation
Charge (pH 7)	-2.70
Kyte-Doolittle Hydrophobicity Value	-0.400
Molecular Weight (kDa)	24.5
Isoelectric Point (pI)	6.25

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name	Definition	Accession	Model Type (?)	SNP	Cutoff	Bit Score	Percent Identity	CARD Version
nalD	NalD is a repressor of MexAB-OprM. Mutations lead to multidrug resistance and MexAB-OprM overexpression. [PMID:15855496]	ARO:3000819	protein overexpression model		Strict	429.5	100.0	3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
5H9T	TRANSCRIPTION REGULATOR	12/29/15	Crystal structure of native NalD at resolution of 2.9, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)	2.89	X-RAY DIFFRACTION	100.0
5DAJ	TRANSCRIPTION REGULATOR	08/20/15	Crystal structure of NalD, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa	Pseudomonas aeruginosa PAO1	2.65	X-RAY DIFFRACTION	100.0

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 330 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002095 (523 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_18080 Search term: TetR family transcriptional regulator

Human Homologs

References