Pseudomonas aeruginosa UCBPP-PA14, PA14_29730 (bqsR)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_29730
Name	bqsR Synonym: carR
Replicon	chromosome
Genomic location	2573895 - 2574566 (+ strand)
Transposon Mutants in orthologs	5 transposon mutants in orthologs
Comment	First described as BqsR in PMID:19513205 (2008). Later referred to as CarR in PMID:26755627 (2016). According to pseudomonas.com guidelines, earlier gene name takes precedence if it appeared in a peer-reviewed scientific publication.

Cross-References

RefSeq	YP_790537.1
GI	116050644
Entrez	4380688
INSDC	ABJ11880.1
NCBI Locus Tag	PA14_29730
UniParc	UPI00000C5791
UniProtKB Acc	Q02NE9
UniProtKB ID	Q02NE9_PSEAB
UniRef100	UniRef100_A0A072ZP29
UniRef50	UniRef50_Q0C2L9
UniRef90	UniRef90_A6V4C2

Product

Feature Type	CDS
Coding Frame	1
Product Name	two-component response regulator BqsR Product Name Confidence: Class 1
Synonyms	two-component response regulator
Evidence for Translation
Charge (pH 7)	-5.14
Kyte-Doolittle Hydrophobicity Value	-0.200
Molecular Weight (kDa)	24.7
Isoelectric Point (pI)	5.85

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 623 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002900 (533 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_29730 Search term: bqsR Search term: two-component response regulator BqsR

Human Homologs

References

A novel two-component system BqsS-BqsR modulates quorum sensing-dependent biofilm decay in Pseudomonas aeruginosa. Dong YH, Zhang XF, An SW, Xu JL, Zhang LH Commun Integr Biol 2008;1(1):88-96 PubMed ID: 19513205

The ferrous iron-responsive BqsRS two-component system activates genes that promote cationic stress tolerance. Kreamer NN, Costa F, Newman DK mBio 2015 Feb 24;6(2):e02549 PubMed ID: 25714721

BqsR/BqsS constitute a two-component system that senses extracellular Fe(II) in Pseudomonas aeruginosa. Kreamer NN, Wilks JC, Marlow JJ, Coleman ML, Newman DK J Bacteriol 2012 Mar;194(5):1195-204 PubMed ID: 22194456