Pseudomonas aeruginosa UCBPP-PA14, PA14_60830 (mexD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_60830
Name
mexD
Replicon chromosome
Genomic location 5423547 - 5426678 (- strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 23 transposon mutants in orthologs

Cross-References

RefSeq YP_793057.1
GI 116052740
Entrez 4384572
INSDC ABJ13976.1
NCBI Locus Tag PA14_60830
UniParc UPI0000396421
UniProtKB Acc Q02G79
UniProtKB ID Q02G79_PSEAB
UniRef100 UniRef100_Q02G79
UniRef50 UniRef50_P31224
UniRef90 UniRef90_Q9HVI9

Product

Feature Type CDS
Coding Frame 1
Product Name
multidrug efflux RND transporter MexD
Synonyms
Evidence for Translation
Charge (pH 7) -16.84
Kyte-Doolittle Hydrophobicity Value 0.403
Molecular Weight (kDa) 111.6
Isoelectric Point (pI) 4.83

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
MexD MexD is the multidrug inner membrane transporter of the MexCD-OprJ complex. [PMID:9449262, PMID:8878035] ARO:3000801 protein homolog model Strict 1831.2 94.48 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 487 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000417 (2093 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_60830
Search term: mexD

Human Homologs

References

No references are associated with this feature.