Pseudomonas aeruginosa PA7, PSPA7_0527 (oprM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PA7
GCF_000017205.1|latest
Locus Tag
PSPA7_0527
Name
oprM
Replicon chromosome
Genomic location 542706 - 544163 (+ strand)

Cross-References

RefSeq YP_001345922.1
GI 152985622
Entrez 5355052
NCBI Locus Tag PSPA7_0527

Product

Feature Type CDS
Coding Frame 1
Product Name
outer membrane protein OprM
Synonyms
Evidence for Translation
Charge (pH 7) -2.79
Kyte-Doolittle Hydrophobicity Value -0.222
Molecular Weight (kDa) 52.7
Isoelectric Point (pI) 5.32

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
OprM OprM is an outer membrane factor protein found in Pseudomonas aeruginosa and Burkholderia vietnamiensis. It is part of the MexAB-OprM, MexVW-OprM, MexXY-OprM and the AmrAB-OprM complex. ARO:3000379 protein homolog model Strict 914.8 99.59 3.0.2

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4Y1K MEMBRANE PROTEIN 02/07/15 PALMITOYLATED OPRM OUTER MEMBRANE FACTOR PSEUDOMONAS AERUGINOSA 3.8 X-RAY DIFFRACTION 99.5
6IOK MEMBRANE PROTEIN 10/30/18 Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state) PSEUDOMONAS AERUGINOSA PAO1 3.64 ELECTRON MICROSCOPY 99.5
1WP1 MEMBRANE PROTEIN 08/28/04 Crystal structure of the drug-discharge outer membrane protein, OprM PSEUDOMONAS AERUGINOSA 2.56 X-RAY DIFFRACTION 99.5
6IOL MEMBRANE PROTEIN 10/30/18 Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state) PSEUDOMONAS AERUGINOSA; PSEUDOMONAS AERUGINOSA PAO1 3.76 ELECTRON MICROSCOPY 99.5
3D5K MEMBRANE PROTEIN 05/16/08 Crystal structure of the OprM channel in a non-symmetrical space group PSEUDOMONAS AERUGINOSA 2.4 X-RAY DIFFRACTION 99.5

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 315 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000418 (551 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PSPA7_0527
Search term: oprM

Human Homologs

References

No references are associated with this feature.