Pseudomonas aeruginosa PA7, PSPA7_0543 (hydA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PA7
GCF_000017205.1|latest |
| Locus Tag |
PSPA7_0543
|
| Name |
hydA
|
| Replicon | chromosome |
| Genomic location | 561172 - 562671 (- strand) |
Cross-References
| RefSeq | YP_001345938.1 |
| GI | 152983496 |
| EC Number | 3.5.2.2 |
| Entrez | 5353967 |
| NCBI Locus Tag | PSPA7_0543 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
phenylhydantoinase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -7.36 |
| Kyte-Doolittle Hydrophobicity Value | -0.220 |
| Molecular Weight (kDa) | 54332.9 |
| Isoelectric Point (pI) | 6.34 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 5E5C | HYDROLASE | 10/08/15 | Crystal structure of dihydropyrimidinase from Pseudomonas aeruginosa PAO1 | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) | 2.1 | X-RAY DIFFRACTION | 98.7 |
| 7E3U | HYDROLASE | 02/09/21 | Crystal structure of the Pseudomonas aeruginosa dihydropyrimidinase complexed with 5-AU | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 2.159 | X-RAY DIFFRACTION | 98.7 |
| 6AJD | HYDROLASE | 08/27/18 | Crystal structure of a monometallic dihydropyrimidinase from Pseudomonas aeruginosa PAO1 reveals no lysine carbamylation within the active site | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 2.223 | X-RAY DIFFRACTION | 98.7 |
| 6KLK | HYDROLASE | 07/30/19 | Crystal structure of the Pseudomonas aeruginosa dihydropyrimidinase complexed with 5-FU | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 1.759 | X-RAY DIFFRACTION | 98.7 |
| 5YKD | HYDROLASE | 10/14/17 | Crystal structure of dihydropyrimidinase from Pseudomonas aeruginosa PAO1 at 2.17 angstrom resolution | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 2.17 | X-RAY DIFFRACTION | 98.7 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 560 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000432 (845 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PSPA7_0543
Search term: hydA
Search term: phenylhydantoinase
|
Human Homologs
|
Ensembl
107, assembly
GRCh38.p13
|
dihydropyrimidinase [Source:HGNC Symbol;Acc:HGNC:3013]
E-value:
2.0e-138
Percent Identity:
51.4
|
References
No references are associated with this feature.