Pseudomonas aeruginosa PA7, PSPA7_4398

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa PA7
GCF_000017205.1|latest
Locus Tag
PSPA7_4398
Name
Replicon chromosome
Genomic location 4527457 - 4528362 (- strand)

Cross-References

RefSeq YP_001349749.1
GI 152984780
Entrez 5357397
NCBI Locus Tag PSPA7_4398

Product

Feature Type CDS
Coding Frame 1
Product Name
quinolone signal response protein
Synonyms
Evidence for Translation
Charge (pH 7) -7.86
Kyte-Doolittle Hydrophobicity Value -0.175
Molecular Weight (kDa) 34.3
Isoelectric Point (pI) 5.60

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
8B4A SIGNALING PROTEIN 09/20/22 Nativ complex of PqsE and RhlR with autoinducer C4-HSL Pseudomonas aeruginosa PAO1 3.06 X-RAY DIFFRACTION 92.4
5HIO METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 2-aminobenzoylacetate Pseudomonas aeruginosa PAO1 1.9 X-RAY DIFFRACTION 92.4
7KGW HYDROLASE/Inhibitor 10/19/20 Structure of PQS Response Protein PqsE in Complex N-(3-(1H-pyrazol-5-yl)phenyl)-1H-indazole-7-carboxamide Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.99 X-RAY DIFFRACTION 92.4
8DQ0 TRANSCRIPTION 07/18/22 Quorum-sensing receptor RhlR bound to PqsE Pseudomonas aeruginosa 3.74 ELECTRON MICROSCOPY 92.4
7R3J TRANSCRIPTION 02/07/22 Nativ complex of PqsE and RhlR with the synthetic antagonist mBTL Pseudomonas aeruginosa PAO1 3.06 X-RAY DIFFRACTION 92.4
2VW8 SIGNALING PROTEIN 06/17/08 Crystal Structure of Quinolone signal response protein pqsE from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA PAO1 1.45 X-RAY DIFFRACTION 92.4
3DH8 METAL BINDING PROTEIN 06/17/08 Structure of Pseudomonas Quinolone Signal Response Protein PqsE Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 92.0
7R3E TRANSCRIPTION 02/07/22 Fusion construct of PqsE and RhlR in complex with the synthetic antagonist mBTL Pseudomonas aeruginosa PAO1 3.46 X-RAY DIFFRACTION 92.4
7R3F HYDROLASE 02/07/22 Monomeric PqsE mutant E187R Pseudomonas aeruginosa PAO1 1.65 X-RAY DIFFRACTION 92.0
5HIQ METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 2-(1H-pyrrol-1-yl)benzoic acid Pseudomonas aeruginosa PAO1 2.1 X-RAY DIFFRACTION 92.4
2Q0I METAL BINDING PROTEIN 05/22/07 Structure of Pseudomonas Quinolone Signal Response Protein PqsE Pseudomonas aeruginosa 1.57 X-RAY DIFFRACTION 92.4
5HIS METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 3-methylthiophene-2-carboxylic acid Pseudomonas aeruginosa PAO1 1.77 X-RAY DIFFRACTION 92.4
2Q0J METAL BINDING PROTEIN 05/22/07 Structure of Pseudomonas Quinolone Signal Response Protein PqsE Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 92.4
5HIP METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 2-(pyridin-3-yl)benzoic acid Pseudomonas aeruginosa PAO1 1.992 X-RAY DIFFRACTION 92.4
7TZA HYDROLASE/INHIBITOR 02/15/22 Structure of PQS Response Protein PqsE in complex with N-(4-(3-neopentylureido)phenyl)-1H-indazole-7-carboxamide Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 92.4
7U6G HYDROLASE 03/04/22 Structure of PQS Response Protein PqsE(E182W,E280A) Variant Pseudomonas aeruginosa 2.45 X-RAY DIFFRACTION 92.0
7TZ9 HYDROLASE 02/15/22 Structure of PQS Response Protein PqsE(E182W) Variant Pseudomonas aeruginosa 2.01 X-RAY DIFFRACTION 92.0
7KGX HYDROLASE/Inhibitor 10/19/20 Structure of PQS Response Protein PqsE in Complex with 4-(3-(2-methyl-2-morpholinobutyl)ureido)-N-(thiazol-2-yl)benzamide Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2 X-RAY DIFFRACTION 92.4
8DQ1 TRANSCRIPTION/DNA 07/18/22 Quorum-sensing receptor RhlR bound to PqsE Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT 4.1 ELECTRON MICROSCOPY 92.4

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 76 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000963 (297 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PSPA7_4398

Human Homologs

References

No references are associated with this feature.