Pseudomonas aeruginosa PA7, PSPA7_4398

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PA7
GCF_000017205.1|latest
Locus Tag
PSPA7_4398
Name
Replicon chromosome
Genomic location 4527457 - 4528362 (- strand)

Cross-References

RefSeq YP_001349749.1
GI 152984780
Entrez 5357397
NCBI Locus Tag PSPA7_4398

Product

Feature Type CDS
Coding Frame 1
Product Name
quinolone signal response protein
Synonyms
Evidence for Translation
Charge (pH 7) -7.86
Kyte-Doolittle Hydrophobicity Value -0.175
Molecular Weight (kDa) 34.3
Isoelectric Point (pI) 5.60

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2Q0I METAL BINDING PROTEIN 05/22/07 Structure of Pseudomonas Quinolone Signal Response Protein PqsE Pseudomonas aeruginosa 1.57 X-RAY DIFFRACTION 92.4
5HIO METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 2-aminobenzoylacetate Pseudomonas aeruginosa PAO1 1.9 X-RAY DIFFRACTION 92.4
7TZA HYDROLASE/INHIBITOR 02/15/22 Structure of PQS Response Protein PqsE in complex with N-(4-(3-neopentylureido)phenyl)-1H-indazole-7-carboxamide Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 92.4
3DH8 METAL BINDING PROTEIN 06/17/08 Structure of Pseudomonas Quinolone Signal Response Protein PqsE Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 92.0
2Q0J METAL BINDING PROTEIN 05/22/07 Structure of Pseudomonas Quinolone Signal Response Protein PqsE Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 92.4
7KGW HYDROLASE/Inhibitor 10/19/20 Structure of PQS Response Protein PqsE in Complex N-(3-(1H-pyrazol-5-yl)phenyl)-1H-indazole-7-carboxamide Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.99 X-RAY DIFFRACTION 92.4
5HIQ METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 2-(1H-pyrrol-1-yl)benzoic acid Pseudomonas aeruginosa PAO1 2.1 X-RAY DIFFRACTION 92.4
7U6G HYDROLASE 03/04/22 Structure of PQS Response Protein PqsE(E182W,E280A) Variant Pseudomonas aeruginosa 2.45 X-RAY DIFFRACTION 92.0
2VW8 SIGNALING PROTEIN 06/17/08 Crystal Structure of Quinolone signal response protein pqsE from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA PAO1 1.45 X-RAY DIFFRACTION 92.4
7TZ9 HYDROLASE 02/15/22 Structure of PQS Response Protein PqsE(E182W) Variant Pseudomonas aeruginosa 2.01 X-RAY DIFFRACTION 92.0
5HIP METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 2-(pyridin-3-yl)benzoic acid Pseudomonas aeruginosa PAO1 1.992 X-RAY DIFFRACTION 92.4
8B4A SIGNALING PROTEIN 09/20/22 Nativ complex of PqsE and RhlR with autoinducer C4-HSL Pseudomonas aeruginosa PAO1 3.06 X-RAY DIFFRACTION 92.4
7R3F HYDROLASE 02/07/22 Monomeric PqsE mutant E187R Pseudomonas aeruginosa PAO1 1.65 X-RAY DIFFRACTION 92.0
8DQ1 TRANSCRIPTION/DNA 07/18/22 Quorum-sensing receptor RhlR bound to PqsE Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT 4.1 ELECTRON MICROSCOPY 92.4
7R3E TRANSCRIPTION 02/07/22 Fusion construct of PqsE and RhlR in complex with the synthetic antagonist mBTL Pseudomonas aeruginosa PAO1 3.46 X-RAY DIFFRACTION 92.4
5HIS METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 3-methylthiophene-2-carboxylic acid Pseudomonas aeruginosa PAO1 1.77 X-RAY DIFFRACTION 92.4
7KGX HYDROLASE/Inhibitor 10/19/20 Structure of PQS Response Protein PqsE in Complex with 4-(3-(2-methyl-2-morpholinobutyl)ureido)-N-(thiazol-2-yl)benzamide Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2 X-RAY DIFFRACTION 92.4
7R3J TRANSCRIPTION 02/07/22 Nativ complex of PqsE and RhlR with the synthetic antagonist mBTL Pseudomonas aeruginosa PAO1 3.06 X-RAY DIFFRACTION 92.4
8DQ0 TRANSCRIPTION 07/18/22 Quorum-sensing receptor RhlR bound to PqsE Pseudomonas aeruginosa 3.74 ELECTRON MICROSCOPY 92.4

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 76 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000963 (297 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PSPA7_4398

Human Homologs

References

No references are associated with this feature.