Pseudomonas aeruginosa PA7, PSPA7_4898 (pyk1)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PA7
GCF_000017205.1|latest |
| Locus Tag |
PSPA7_4898
|
| Name |
pyk1
|
| Replicon | chromosome |
| Genomic location | 5051250 - 5052701 (+ strand) |
Cross-References
| RefSeq | YP_001350234.1 |
| GI | 152985356 |
| EC Number | 2.7.1.40 |
| Entrez | 5358229 |
| NCBI Locus Tag | PSPA7_4898 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
pyruvate kinase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -3.24 |
| Kyte-Doolittle Hydrophobicity Value | -0.095 |
| Molecular Weight (kDa) | 52.3 |
| Isoelectric Point (pI) | 6.52 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 6QXL | TRANSFERASE | 03/07/19 | Crystal Structure of Pyruvate Kinase II (PykA) from Pseudomonas aeruginosa in complex with sodium malonate, magnesium and glucose-6-phosphate | Pseudomonas aeruginosa | 2.43 | X-RAY DIFFRACTION | 98.8 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 614 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG003926 (537 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PSPA7_4898
Search term: pyk1
Search term: pyruvate kinase
|
Human Homologs
|
Ensembl
110, assembly
GRCh38.p14
|
pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021]
E-value:
2.0e-66
Percent Identity:
35.5
|
|
Ensembl
110, assembly
GRCh38.p14
|
pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021]
E-value:
2.0e-66
Percent Identity:
35.5
|
|
Ensembl
110, assembly
GRCh38.p14
|
pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021]
E-value:
2.0e-66
Percent Identity:
35.5
|
|
Ensembl
110, assembly
GRCh38.p14
|
pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021]
E-value:
2.0e-66
Percent Identity:
35.5
|
References
No references are associated with this feature.