Pseudomonas aeruginosa PA7, PSPA7_4986 (murD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PA7
GCF_000017205.1|latest
Locus Tag
PSPA7_4986
Name
murD
Replicon chromosome
Genomic location 5142304 - 5143650 (- strand)

Cross-References

RefSeq YP_001350322.1
GI 152985250
EC Number 6.3.2.9
Entrez 5359826
INSDC ABR82433.1
NCBI Locus Tag PSPA7_4986
UniParc UPI00000C5D03
UniProtKB Acc A6VB87
UniProtKB ID A6VB87_PSEA7
UniRef100 UniRef100_Q9HVZ9
UniRef50 UniRef50_Q9HVZ9
UniRef90 UniRef90_Q9HVZ9

Product

Feature Type CDS
Coding Frame 1
Product Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Synonyms
Evidence for Translation
Charge (pH 7) -6.27
Kyte-Doolittle Hydrophobicity Value 0.125
Molecular Weight (kDa) 48.1
Isoelectric Point (pI) 5.70

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7SY9 LIGASE 11/24/21 Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.75 X-RAY DIFFRACTION 100.0
8DP2 LIGASE 07/14/22 Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 in complex with UMA (Uridine-5'-diphosphate-N-acetylmuramoyl-L-Alanine) Pseudomonas aeruginosa PAO1 1.6 X-RAY DIFFRACTION 100.0
7U35 LIGASE 02/25/22 Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 in complex with ADP Pseudomonas aeruginosa PAO1 1.95 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 574 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004004 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PSPA7_4986
Search term: murD

Human Homologs

References

No references are associated with this feature.