Pseudomonas aeruginosa M18, PAM18_1169 (guaB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa M18
GCF_000226155.1|latest
Locus Tag
PAM18_1169
Name
guaB
Replicon chromosome
Genomic location 1272306 - 1273775 (+ strand)

Cross-References

RefSeq YP_005973758.1
GI 386057236
Entrez 12565198
NCBI Locus Tag PAM18_1169

Product

Feature Type CDS
Coding Frame 1
Product Name
inosine 5'-monophosphate dehydrogenase
Synonyms
Evidence for Translation
Charge (pH 7) -1.36
Kyte-Doolittle Hydrophobicity Value 0.027
Molecular Weight (kDa) 51.7
Isoelectric Point (pI) 6.65

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3ZFH OXIDOREDUCTASE 12/11/12 Crystal structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase PSEUDOMONAS AERUGINOSA PAO1 2.25 X-RAY DIFFRACTION 100.0
6GJV OXIDOREDUCTASE 05/17/18 apo-structure of IMPDH from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 2.11 X-RAY DIFFRACTION 100.0
4DQW OXIDOREDUCTASE 02/16/12 Crystal Structure Analysis of PA3770 Pseudomonas aeruginosa 2.51 X-RAY DIFFRACTION 100.0
6GK9 OXIDOREDUCTASE 05/18/18 Inhibited structure of IMPDH from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 2.54 X-RAY DIFFRACTION 100.0
7PJI OXIDOREDUCTASE 08/24/21 Crystal structure of Pseudomonas aeruginosa guaB (IMP dehydrogenase) bound to ATP and GDP at 1.65A resolution Pseudomonas aeruginosa 1.65 X-RAY DIFFRACTION 100.0
4AVF OXIDOREDUCTASE 05/25/12 Crystal structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase PSEUDOMONAS AERUGINOSA 2.23 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 631 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001893 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PAM18_1169
Search term: guaB

Human Homologs

Ensembl 110, assembly GRCh38.p14
inosine monophosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:6052]
E-value: 5.9e-90
Percent Identity: 42.1
Ensembl 110, assembly GRCh38.p14
inosine monophosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:6052]
E-value: 5.9e-90
Percent Identity: 42.1
Ensembl 110, assembly GRCh38.p14
inosine monophosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:6052]
E-value: 5.9e-90
Percent Identity: 42.1

References

No references are associated with this feature.