Pseudomonas aeruginosa M18, PAM18_4505 (murD)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa M18
GCF_000226155.1|latest |
| Locus Tag |
PAM18_4505
|
| Name |
murD
|
| Replicon | chromosome |
| Genomic location | 4986964 - 4988310 (- strand) |
Cross-References
| RefSeq | YP_005977088.1 |
| GI | 386060566 |
| Entrez | 12568572 |
| NCBI Locus Tag | PAM18_4505 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -6.27 |
| Kyte-Doolittle Hydrophobicity Value | 0.125 |
| Molecular Weight (kDa) | 48.1 |
| Isoelectric Point (pI) | 5.70 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 7U35 | LIGASE | 02/25/22 | Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 in complex with ADP | Pseudomonas aeruginosa PAO1 | 1.95 | X-RAY DIFFRACTION | 100.0 |
| 7SY9 | LIGASE | 11/24/21 | Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 2.75 | X-RAY DIFFRACTION | 100.0 |
| 8DP2 | LIGASE | 07/14/22 | Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 in complex with UMA (Uridine-5'-diphosphate-N-acetylmuramoyl-L-Alanine) | Pseudomonas aeruginosa PAO1 | 1.6 | X-RAY DIFFRACTION | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 574 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG004004 (535 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PAM18_4505
Search term: murD
Search term: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
|
Human Homologs
References
No references are associated with this feature.