Pseudomonas aeruginosa DK2, PADK2_22560

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa DK2
GCF_000271365.1|latest
Locus Tag
PADK2_22560
Name
Replicon chromosome
Genomic location 4865459 - 4866910 (+ strand)

Cross-References

RefSeq YP_006484477.1
GI 392985890
EC Number 2.7.1.40
Entrez 13173189
NCBI Locus Tag PADK2_22560

Product

Feature Type CDS
Coding Frame 1
Product Name
pyruvate kinase
Synonyms
Evidence for Translation
Charge (pH 7) -2.24
Kyte-Doolittle Hydrophobicity Value -0.092
Molecular Weight (kDa) 52.3
Isoelectric Point (pI) 6.66

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6QXL TRANSFERASE 03/07/19 Crystal Structure of Pyruvate Kinase II (PykA) from Pseudomonas aeruginosa in complex with sodium malonate, magnesium and glucose-6-phosphate Pseudomonas aeruginosa 2.43 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 614 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003926 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PADK2_22560
Search term: pyruvate kinase

Human Homologs

Ensembl 110, assembly GRCh38.p14
pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021]
E-value: 3.1e-67
Percent Identity: 36.7
Ensembl 110, assembly GRCh38.p14
pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021]
E-value: 3.1e-67
Percent Identity: 36.7
Ensembl 110, assembly GRCh38.p14
pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021]
E-value: 3.1e-67
Percent Identity: 36.7
Ensembl 110, assembly GRCh38.p14
pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021]
E-value: 3.1e-67
Percent Identity: 36.7

References

No references are associated with this feature.