Pseudomonas aeruginosa B136-33, G655_02165

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa B136-33
GCF_000359505.1|latest
Locus Tag
G655_02165
Name
Replicon chromosome
Genomic location 463905 - 465038 (+ strand)

Cross-References

RefSeq YP_007707282.1
GI 478476631
Entrez 15133347
NCBI Locus Tag G655_02165

Product

Feature Type CDS
Coding Frame 1
Product Name
RND multidrug efflux membrane fusion protein
Synonyms
Evidence for Translation
Charge (pH 7) 2.22
Kyte-Doolittle Hydrophobicity Value -0.215
Molecular Weight (kDa) 40.3
Isoelectric Point (pI) 8.83

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
MexA MexA is the membrane fusion protein of the MexAB-OprM multidrug efflux complex. [PMID:15117957] ARO:3000377 protein homolog model Strict 704.5 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1T5E TRANSPORT PROTEIN 05/04/04 The structure of MexA Pseudomonas aeruginosa 3 X-RAY DIFFRACTION 100.0
6TA5 ANTIMICROBIAL PROTEIN 10/29/19 OprM-MexA complex from the MexAB-OprM Pseudomonas aeruginosa whole assembly reconstituted in nanodiscs Pseudomonas aeruginosa 3.2 ELECTRON MICROSCOPY 100.0
6TA6 ANTIMICROBIAL PROTEIN 10/29/19 MexAB assembly of the Pseudomonas MexAB-OprM efflux pump reconstituted in nanodiscs Pseudomonas aeruginosa 3.2 ELECTRON MICROSCOPY 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 394 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000416 (526 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: G655_02165

Human Homologs

References

No references are associated with this feature.