Pseudomonas aeruginosa RP73, M062_18930

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa RP73
GCF_000414035.1|latest
Locus Tag
M062_18930
Name
Replicon chromosome
Genomic location 4063199 - 4063837 (+ strand)

Cross-References

RefSeq YP_008134195.1
GI 514410772
Entrez 15961525
NCBI Locus Tag M062_18930

Product

Feature Type CDS
Coding Frame 1
Product Name
TetR family transcriptional regulator
Synonyms
Evidence for Translation
Charge (pH 7) -1.46
Kyte-Doolittle Hydrophobicity Value -0.399
Molecular Weight (kDa) 24.5
Isoelectric Point (pI) 6.63

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
nalD NalD is a repressor of MexAB-OprM. Mutations lead to multidrug resistance and MexAB-OprM overexpression. ARO:3000819 protein overexpression model Strict 426.8 99.53 3.0.2

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5DAJ TRANSCRIPTION REGULATOR 08/20/15 Crystal structure of NalD, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA PAO1 2.65 X-RAY DIFFRACTION 99.5
5H9T TRANSCRIPTION REGULATOR 12/29/15 Crystal structure of native NalD at resolution of 2.9, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA (STRAIN ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 2.89 X-RAY DIFFRACTION 99.5

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 331 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002095 (539 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: M062_18930

Human Homologs

References

No references are associated with this feature.