Pseudomonas aeruginosa RP73, M062_23240 (murC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa RP73
GCF_000414035.1|latest
Locus Tag
M062_23240
Name
murC
Replicon chromosome
Genomic location 5009136 - 5010578 (- strand)

Cross-References

RefSeq YP_008135046.1
GI 514411565
EC Number 6.3.2.8
Entrez 15962386
NCBI Locus Tag M062_23240

Product

Feature Type CDS
Coding Frame 1
Product Name
UDP-N-acetylmuramate--alanine ligase
Synonyms
Evidence for Translation
Charge (pH 7) -6.22
Kyte-Doolittle Hydrophobicity Value 0.013
Molecular Weight (kDa) 51.9
Isoelectric Point (pI) 6.10

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
8EGM LIGASE 09/12/22 Crystal Structure of UDP-N-acetylmuramate-L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase, MurC) Pseudomonas aeruginosa in complex with compound AZ13644908 Pseudomonas aeruginosa PAO1 2.2 X-RAY DIFFRACTION 100.0
6X9N LIGASE 06/03/20 Pseudomonas aeruginosa MurC with AZ5595 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.25 X-RAY DIFFRACTION 100.0
5VVW LIGASE 05/21/17 Structure of MurC from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.3 X-RAY DIFFRACTION 100.0
6X9F LIGASE 06/02/20 Pseudomonas aeruginosa MurC with AZ8074 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.35 X-RAY DIFFRACTION 100.0
8DOF LIGASE 07/13/22 Pseudomonas aeruginosa MurC with WYH9-2-P - OSA_001044 Pseudomonas aeruginosa 2.6 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 583 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004001 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: M062_23240
Search term: murC

Human Homologs

References

No references are associated with this feature.