Pseudomonas aeruginosa RP73, M062_23275

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa RP73
GCF_000414035.1|latest
Locus Tag
M062_23275
Name
Replicon chromosome
Genomic location 5018107 - 5019846 (- strand)

Cross-References

RefSeq YP_008135053.1
GI 514411572
Entrez 15962393
NCBI Locus Tag M062_23275

Product

Feature Type CDS
Coding Frame 1
Product Name
cell division protein
Synonyms
Evidence for Translation
Charge (pH 7) 16.14
Kyte-Doolittle Hydrophobicity Value -0.129
Molecular Weight (kDa) 62827.7
Isoelectric Point (pI) 10.04

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7ATX HYDROLASE 11/01/20 Structure of P. aeruginosa PBP3 in complex with a benzoxaborole (Compound 4) Pseudomonas aeruginosa 1.795 X-RAY DIFFRACTION 99.4
8BH1 MEMBRANE PROTEIN 10/28/22 Core divisome complex FtsWIQBL from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 3.8 ELECTRON MICROSCOPY 99.8
6HR4 PENICILLIN-BINDING PROTEIN 09/26/18 Apo form of penicillin-binding protein 3 from P. aeruginosa Pseudomonas aeruginosa PAO1 1.19 X-RAY DIFFRACTION 99.4
7KIV HYDROLASE/Inhibitor/Antibiotic 10/24/20 Crystal structure of Pseudomonas aeruginosa PBP3 in complex with avibactam Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.389 X-RAY DIFFRACTION 99.8
6HR6 PENICILLIN-BINDING PROTEIN 09/26/18 Nitrocefin reacted with catalytic serine (Ser294) of penicillin-binding protein 3 from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.53 X-RAY DIFFRACTION 99.4
6I1E PEPTIDE BINDING PROTEIN 10/28/18 Crystal structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3 in complex with amoxicillin Pseudomonas aeruginosa 1.64 X-RAY DIFFRACTION 99.4
4KQQ Biosynthetic Protein/Antibiotic 05/15/13 CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-Penicilloic Acid Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 99.8
3OC2 PENICILLIN-BINDING PROTEIN 08/09/10 Crystal structure of penicillin-binding protein 3 from Pseudomonas aeruginosa Pseudomonas aeruginosa 1.968 X-RAY DIFFRACTION 99.8
3OCN PENICILLIN-BINDING PROTEIN/ANTIBIOTIC 08/10/10 Crystal structure of penicillin-binding protein 3 from Pseudomonas aeruginosa in complex with ceftazidime Pseudomonas aeruginosa 2.61 X-RAY DIFFRACTION 99.8
5DF9 TRANSFERASE 08/26/15 CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 IN COMPLEX WITH DEACYLATED PRODUCT OF CEFOPERAZONE Pseudomonas aeruginosa 2.7 X-RAY DIFFRACTION 99.8
7ATO HYDROLASE 10/30/20 Structure of P. aeruginosa PBP3 in complex with an aryl boronic acid (Compound 2) Pseudomonas aeruginosa PAO1 1.587 X-RAY DIFFRACTION 99.4
4KQR Biosynthetic Protein/Antibiotic 05/15/13 CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-Penicilloic Acid Pseudomonas aeruginosa 2.01 X-RAY DIFFRACTION 99.8
7ATW HYDROLASE 11/01/20 Structure of P. aeruginosa PBP3 in complex with a benzoxaborole (Compound 3) Pseudomonas aeruginosa 1.44 X-RAY DIFFRACTION 99.4
5DF7 TRANSFERASE 08/26/15 CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH AZLOCILLIN Pseudomonas aeruginosa 2 X-RAY DIFFRACTION 99.8
5DF8 TRANSFERASE 08/26/15 CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH CEFOPERAZONE Pseudomonas aeruginosa 2 X-RAY DIFFRACTION 99.8
3OCL PENICILLIN-BINDING PROTEIN/ANTIBIOTIC 08/10/10 Crystal structure of penicillin-binding protein 3 from Pseudomonas aeruginosa in complex with carbenicillin Pseudomonas aeruginosa 2.3 X-RAY DIFFRACTION 99.8
7ATM HYDROLASE 10/30/20 Structure of P. aeruginosa PBP3 in complex with a phenyl boronic acid (Compound 1) Pseudomonas aeruginosa PAO1 1.582 X-RAY DIFFRACTION 99.4
7KIT HYDROLASE/Inhibitor/Antibiotic 10/24/20 Crystal structure of Pseudomonas aeruginosa PBP3 in complex with WCK 4234 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.089 X-RAY DIFFRACTION 99.8
7KIW HYDROLASE/Inhibitor/Antibiotic 10/25/20 Crystal structure of Pseudomonas aeruginosa PBP3 in complex with zidebactam Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.49 X-RAY DIFFRACTION 99.8
4KQO Biosynthetic Protein/Antibiotic 05/15/13 Crystal structure of penicillin-binding protein 3 from pseudomonas aeruginosa in complex with piperacillin Pseudomonas aeruginosa 2.31 X-RAY DIFFRACTION 99.8

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Ceftolozane DB09050 DrugBank 5.1.4 Q51504 Cell division protein 99.8 579 0.0e+00
Cefepime DB01413 DrugBank 5.1.4 Q51504 Cell division protein 99.8 579 0.0e+00
Cloxacillin DB01147 DrugBank 5.1.4 Q51504 Cell division protein 99.8 579 0.0e+00
Doripenem DB06211 DrugBank 5.1.4 Q51504 Cell division protein 99.8 579 0.0e+00

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 575 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004008 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: M062_23275

Human Homologs

References

No references are associated with this feature.