Pseudomonas entomophila L48, PSEEN3253 (dht)

Gene Feature Overview

Strain	Pseudomonas entomophila L48 GCF_000026105.1|latest
Locus Tag	PSEEN3253
Name	dht
Replicon	chromosome
Genomic location	3512914 - 3514353 (- strand)

Cross-References

RefSeq	YP_608802.1
GI	104782304
EC Number	3.5.2.2
Entrez	4086483
INSDC	CAK16011.1
UniParc	UPI0000D78A21
UniProtKB Acc	Q1I8L7
UniProtKB ID	Q1I8L7_PSEE4
UniRef100	UniRef100_Q1I8L7
UniRef50	UniRef50_Q59699
UniRef90	UniRef90_Q9I676

Product

Feature Type	CDS
Coding Frame	1
Product Name	phenylhydantoinase
Synonyms
Evidence for Translation
Charge (pH 7)	-11.36
Kyte-Doolittle Hydrophobicity Value	-0.257
Molecular Weight (kDa)	52572.8
Isoelectric Point (pI)	5.98

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
5E5C	HYDROLASE	10/08/15	Crystal structure of dihydropyrimidinase from Pseudomonas aeruginosa PAO1	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)	2.1	X-RAY DIFFRACTION	91.6
6AJD	HYDROLASE	08/27/18	Crystal structure of a monometallic dihydropyrimidinase from Pseudomonas aeruginosa PAO1 reveals no lysine carbamylation within the active site	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2.223	X-RAY DIFFRACTION	91.6
7E3U	HYDROLASE	02/09/21	Crystal structure of the Pseudomonas aeruginosa dihydropyrimidinase complexed with 5-AU	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2.159	X-RAY DIFFRACTION	91.4
5YKD	HYDROLASE	10/14/17	Crystal structure of dihydropyrimidinase from Pseudomonas aeruginosa PAO1 at 2.17 angstrom resolution	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2.17	X-RAY DIFFRACTION	91.4
6KLK	HYDROLASE	07/30/19	Crystal structure of the Pseudomonas aeruginosa dihydropyrimidinase complexed with 5-FU	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.759	X-RAY DIFFRACTION	91.4

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 561 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000432 (819 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PSEEN3253 Search term: dht Search term: phenylhydantoinase

Human Homologs

Ensembl 110, assembly GRCh38.p14

ENSP00000276651 dihydropyrimidinase [Source:HGNC Symbol;Acc:HGNC:3013] E-value: 1.8e-139 Percent Identity: 51.4

References