Pseudomonas protegens CHA0, PFLCHA0_c50300 (lpxC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas protegens CHA0 - Assembly GCF_000397205.1
GCF_000397205.1|latest
Locus Tag
PFLCHA0_c50300
Name
lpxC
Replicon chromosome
Genomic location 5637671 - 5638582 (- strand)

Cross-References

RefSeq YP_008002283.1
GI 501682457
EC Number 3.5.1.-
Entrez 15562946
NCBI Locus Tag PFLCHA0_c50300

Product

Feature Type CDS
Coding Frame 1
Product Name
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase LpxC
Synonyms
Evidence for Translation
Charge (pH 7) -11.58
Kyte-Doolittle Hydrophobicity Value -0.029
Molecular Weight (kDa) 33.3
Isoelectric Point (pI) 4.73

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4FW7 HYDROLASE/HYDROLASE INHIBITOR 06/30/12 Crystal Structure of the LpxC in complex with N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]BIPHENYL-4-CARBOXAMIDE inhibitor Pseudomonas aeruginosa 1.7 X-RAY DIFFRACTION 92.3
5UPG HYDROLASE 02/02/17 Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PF-5081090 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.7 X-RAY DIFFRACTION 92.4
6CAX hydrolase/hydrolase inhibitor 02/01/18 Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PT805 Pseudomonas aeruginosa 1.25 X-RAY DIFFRACTION 92.4
6C9C hydrolase/hydrolase inhibitor 01/26/18 Crystal structure of LpxC from Pseudomonas aeruginosa in complex with racemic ligand PT803 Pseudomonas aeruginosa (strain UCBPP-PA14) 2 X-RAY DIFFRACTION 92.4
6MAE HYDROLASE 08/27/18 CHAIN A. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase PA-LPXC Complexed with (R)-3-((S)-3-(4-(cyclopropylethynyl)phenyl)-2-oxooxazolidin-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)propenamide Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.8 X-RAY DIFFRACTION 92.6
7K99 HYDROLASE 09/28/20 Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor 19 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.9 X-RAY DIFFRACTION 92.4
7K9A HYDROLASE 09/29/20 Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2 X-RAY DIFFRACTION 92.4
4LCG HYDROLASE/ANTIBIOTIC 06/21/13 Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-050 complex Pseudomonas aeruginosa 1.568 X-RAY DIFFRACTION 92.3
7CID HYDROLASE 07/07/20 Crystal structure of P.aeruginosa LpxC in complex with inhibitor Pseudomonas aeruginosa PAO1 2.49 X-RAY DIFFRACTION 92.3
5VWM Hydrolase/Hydrolase Inhibitor 05/22/17 Crystal structure of UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) from Pseudomonas aeruginosa in complex with CHIR-090 inhibitor Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.8 X-RAY DIFFRACTION 92.4
6MOD HYDROLASE/INHIBITOR 10/04/18 Co-Crystal structure of P. aeruginosa LpxC-50432 complex Pseudomonas aeruginosa 1.85 X-RAY DIFFRACTION 92.3
6DUI hydrolase/hydrolase inhibitor 06/20/18 Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PT801 Pseudomonas aeruginosa (strain LESB58) 1.55 X-RAY DIFFRACTION 92.4
5DRR hydrolase/hydrolase inhibitor 09/16/15 Crystal structure of the Pseudomonas aeruginosa LpxC/LPC-058 complex Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 1.59 X-RAY DIFFRACTION 92.3
5N8C HYDROLASE 02/23/17 Crystal structure of Pseudomonas aeruginosa LpxC complexed with inhibitor Pseudomonas aeruginosa 1.9 X-RAY DIFFRACTION 92.1
8E4A BIOSYNTHETIC PROTEIN 08/17/22 Pseudomonas LpxC in complex with LPC-233 Pseudomonas aeruginosa 2.034 X-RAY DIFFRACTION 92.3
5U3B HYDROLASE 12/01/16 Pseudomonas aeruginosa LpxC in complex with NVS-LPXC-01 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2 X-RAY DIFFRACTION 92.6
6E54 hydrolase/hydrolase inhibitor 07/19/18 Crystal structure of LpxC from Pseudomonas aeruginosa in complex with ligand PT802 Pseudomonas aeruginosa 1.65 X-RAY DIFFRACTION 92.4
6MO4 HYDROLASE/INHIBITOR 10/04/18 Co-Crystal structure of P. aeruginosa LpxC-50067 complex Pseudomonas aeruginosa PAO1 1.844 X-RAY DIFFRACTION 92.6
6MO5 HYDROLASE/INHIBITOR 10/04/18 Co-Crystal structure of P. aeruginosa LpxC-50228 complex Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.851 X-RAY DIFFRACTION 92.3
4LCF HYDROLASE/ANTIBIOTIC 06/21/13 Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-014 complex Pseudomonas aeruginosa 1.599 X-RAY DIFFRACTION 92.3

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 387 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003996 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PFLCHA0_c50300
Search term: lpxC

Human Homologs

References

No references are associated with this feature.