Pseudomonas denitrificans ATCC 13867, H681_01075

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas denitrificans ATCC 13867
GCF_000349845.1|latest
Locus Tag
H681_01075
Name
Replicon chromosome
Genomic location 241675 - 243510 (+ strand)

Cross-References

RefSeq YP_007655637.1
GI 472323391
EC Number 2.6.1.16
Entrez 14994355
NCBI Locus Tag H681_01075

Product

Feature Type CDS
Coding Frame 1
Product Name
glucosamine--fructose-6-phosphate aminotransferase
Synonyms
Evidence for Translation
Charge (pH 7) -7.83
Kyte-Doolittle Hydrophobicity Value -0.031
Molecular Weight (kDa) 66375.5
Isoelectric Point (pI) 6.37

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
2-Deoxy-2-Amino Glucitol-6-Phosphate DB02445 DrugBank 5.1.4 P17169 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 64.5 611 3.1e-224
2-(N-Morpholino)-Ethanesulfonic Acid DB03814 DrugBank 5.1.4 P17169 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 64.5 611 3.1e-224
Glucosamine 6-Phosphate DB02657 DrugBank 5.1.4 P17169 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 64.5 611 3.1e-224
Glutamine hydroxamate DB02446 DrugBank 5.1.4 P17169 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 64.5 611 3.1e-224
Glucose-6-Phosphate DB03581 DrugBank 5.1.4 P17169 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 64.5 611 3.1e-224
alpha-D-glucose 6-phosphate DB02007 DrugBank 5.1.4 P17169 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 64.5 611 3.1e-224

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 649 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG005080 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: H681_01075

Human Homologs

Ensembl 110, assembly GRCh38.p14
glutamine-fructose-6-phosphate transaminase 2 [Source:HGNC Symbol;Acc:HGNC:4242]
E-value: 2.9e-110
Percent Identity: 37.4

References

No references are associated with this feature.