Pseudomonas denitrificans ATCC 13867, H681_20345

Gene Feature Overview

Strain	Pseudomonas denitrificans ATCC 13867 GCF_000349845.1|latest
Locus Tag	H681_20345
Name
Replicon	chromosome
Genomic location	4554853 - 4556304 (+ strand)

Cross-References

RefSeq	YP_007659476.1
GI	472327230
EC Number	2.7.1.40
Entrez	14998194
INSDC	AGI25936.1
NCBI Locus Tag	H681_20345
UniParc	UPI0002C4F34D
UniProtKB Acc	M4X2Z2
UniProtKB ID	M4X2Z2_PSEDE
UniRef100	UniRef100_M4X2Z2
UniRef50	UniRef50_P21599
UniRef90	UniRef90_Q02HB2

Product

Feature Type	CDS
Coding Frame	1
Product Name	pyruvate kinase
Synonyms
Evidence for Translation
Charge (pH 7)	-3.24
Kyte-Doolittle Hydrophobicity Value	-0.061
Molecular Weight (kDa)	52206.4
Isoelectric Point (pI)	6.52

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
6QXL	TRANSFERASE	03/07/19	Crystal Structure of Pyruvate Kinase II (PykA) from Pseudomonas aeruginosa in complex with sodium malonate, magnesium and glucose-6-phosphate	Pseudomonas aeruginosa	2.43	X-RAY DIFFRACTION	92.1

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 614 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG003926 (537 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: H681_20345 Search term: pyruvate kinase

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000455736 pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021] E-value: 1.4e-70 Percent Identity: 36.7
Ensembl 110, assembly GRCh38.p14	ENSP00000456970 pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021] E-value: 1.4e-70 Percent Identity: 36.7
Ensembl 110, assembly GRCh38.p14	ENSP00000455901 pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021] E-value: 1.4e-70 Percent Identity: 36.7
Ensembl 110, assembly GRCh38.p14	ENSP00000320171 pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021] E-value: 1.4e-70 Percent Identity: 36.7

References