Pseudomonas aeruginosa LESB58, PALES_01841 (atsA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest |
| Locus Tag |
PALES_01841
|
| Name |
atsA
|
| Replicon | chromosome |
| Genomic location | 206753 - 208363 (- strand) |
Cross-References
| RefSeq | YP_002437792 |
| GI | 218888928 |
| Entrez | 7175301 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
arylsulfatase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -12.39 |
| Kyte-Doolittle Hydrophobicity Value | -0.376 |
| Molecular Weight (kDa) | 59.9 |
| Isoelectric Point (pI) | 5.51 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 4CXK | HYDROLASE | 04/07/14 | G9 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa | PSEUDOMONAS AERUGINOSA | 1.86 | X-RAY DIFFRACTION | 97.9 |
| 4CXU | HYDROLASE | 04/08/14 | G4 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa, in complex with 3-Br-Phenolphenylphosphonate | PSEUDOMONAS AERUGINOSA | 2.03 | X-RAY DIFFRACTION | 98.5 |
| 4CYR | HYDROLASE | 04/14/14 | G4 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa | PSEUDOMONAS AERUGINOSA | 1.72 | X-RAY DIFFRACTION | 98.5 |
| 4CYS | HYDROLASE | 04/14/14 | G6 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa, in complex with Phenylphosphonic acid | PSEUDOMONAS AERUGINOSA | 1.88 | X-RAY DIFFRACTION | 98.5 |
| 1HDH | HYDROLASE | 11/16/00 | Arylsulfatase from Pseudomonas aeruginosa | Pseudomonas aeruginosa | 1.3 | X-RAY DIFFRACTION | 99.6 |
| 4CXS | HYDROLASE | 04/08/14 | G4 mutant of PAS, arylsulfatase from Pseudomonas aeruginosa, in complex with Phenylphosphonic acid | PSEUDOMONAS AERUGINOSA | 2.3 | X-RAY DIFFRACTION | 98.5 |
| 5AJ9 | HYDROLASE | 02/20/15 | G7 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa | PSEUDOMONAS AERUGINOSA | 2 | X-RAY DIFFRACTION | 98.3 |
Drugs Targeting this Protein
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
| Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
| 2-Aminopropanedioic Acid | DB02289 | DrugBank | 5.1.4 | P51691 | Arylsulfatase | 99.8 | 536 | 0.0e+00 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 243 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000181 (366 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PALES_01841
Search term: atsA
Search term: arylsulfatase
|
Human Homologs
|
Ensembl
110, assembly
GRCh38.p14
|
arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714]
E-value:
3.4e-30
Percent Identity:
29.9
|
|
Ensembl
110, assembly
GRCh38.p14
|
arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714]
E-value:
3.4e-30
Percent Identity:
29.9
|
|
Ensembl
110, assembly
GRCh38.p14
|
arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714]
E-value:
3.4e-30
Percent Identity:
29.9
|
References
No references are associated with this feature.