Pseudomonas aeruginosa LESB58, PALES_04391 (dht)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest
Locus Tag
PALES_04391
Name
dht
Replicon chromosome
Genomic location 488557 - 489996 (- strand)

Cross-References

RefSeq YP_002438047
GI 218889183
Entrez 7175468

Product

Feature Type CDS
Coding Frame 1
Product Name
phenylhydantoinase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -10.36
Kyte-Doolittle Hydrophobicity Value -0.162
Molecular Weight (kDa) 52.1
Isoelectric Point (pI) 6.08

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6AJD HYDROLASE 08/27/18 Crystal structure of a monometallic dihydropyrimidinase from Pseudomonas aeruginosa PAO1 reveals no lysine carbamylation within the active site Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.223 X-RAY DIFFRACTION 99.8
5E5C HYDROLASE 10/08/15 Crystal structure of dihydropyrimidinase from Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 2.1 X-RAY DIFFRACTION 99.8
6KLK HYDROLASE 07/30/19 Crystal structure of the Pseudomonas aeruginosa dihydropyrimidinase complexed with 5-FU Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.759 X-RAY DIFFRACTION 99.8
7E3U HYDROLASE 02/09/21 Crystal structure of the Pseudomonas aeruginosa dihydropyrimidinase complexed with 5-AU Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.159 X-RAY DIFFRACTION 99.8
5YKD HYDROLASE 10/14/17 Crystal structure of dihydropyrimidinase from Pseudomonas aeruginosa PAO1 at 2.17 angstrom resolution Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.17 X-RAY DIFFRACTION 99.8

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 561 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000432 (819 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PALES_04391
Search term: dht

Human Homologs

Ensembl 110, assembly GRCh38.p14
dihydropyrimidinase [Source:HGNC Symbol;Acc:HGNC:3013]
E-value: 2.2e-137
Percent Identity: 51.2

References

No references are associated with this feature.