Pseudomonas aeruginosa LESB58, PALES_14591
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest |
| Locus Tag |
PALES_14591
|
| Name |
|
| Replicon | chromosome |
| Genomic location | 1574801 - 1575439 (- strand) |
Cross-References
| RefSeq | YP_002439063 |
| GI | 218890199 |
| Entrez | 7176208 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
putative transcriptional regulator
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -1.46 |
| Kyte-Doolittle Hydrophobicity Value | -0.399 |
| Molecular Weight (kDa) | 24.5 |
| Isoelectric Point (pI) | 6.63 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AMR gene predictions from CARD database
Identified using the Resistance Gene Identifier (RGI)
| Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
| nalD | NalD is a repressor of MexAB-OprM. Mutations lead to multidrug resistance and MexAB-OprM overexpression. [PMID:15855496] | ARO:3000819 | protein overexpression model | Strict | 426.8 | 99.53 | 3.2.5 |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 5H9T | TRANSCRIPTION REGULATOR | 12/29/15 | Crystal structure of native NalD at resolution of 2.9, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) | 2.89 | X-RAY DIFFRACTION | 99.5 |
| 5DAJ | TRANSCRIPTION REGULATOR | 08/20/15 | Crystal structure of NalD, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa | Pseudomonas aeruginosa PAO1 | 2.65 | X-RAY DIFFRACTION | 99.5 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 331 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG002095 (523 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PALES_14591
Search term: putative transcriptional regulator
|
Human Homologs
References
No references are associated with this feature.