Pseudomonas aeruginosa 2192, PA2G_04100

Gene Feature Overview

Strain	Pseudomonas aeruginosa 2192 GCF_000152545.1|latest
Locus Tag	PA2G_04100
Name
Replicon	chromosome
Genomic location	4585184 - 4586794 (- strand)

Cross-References

RefSeq	ZP_04936614.1
GI	254243292
NCBI Locus Tag	PA2G_04100
UniProtKB Acc	A3LH02
UniProtKB ID	A3LH02_PSEAE

Product

Feature Type	CDS
Coding Frame	1
Product Name	arylsulfatase
Synonyms
Evidence for Translation
Charge (pH 7)	-12.39
Kyte-Doolittle Hydrophobicity Value	-0.378
Molecular Weight (kDa)	59.9
Isoelectric Point (pI)	5.51

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
4CXU	HYDROLASE	04/08/14	G4 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa, in complex with 3-Br-Phenolphenylphosphonate	PSEUDOMONAS AERUGINOSA	2.03	X-RAY DIFFRACTION	98.7
1HDH	HYDROLASE	11/16/00	Arylsulfatase from Pseudomonas aeruginosa	Pseudomonas aeruginosa	1.3	X-RAY DIFFRACTION	99.8
5AJ9	HYDROLASE	02/20/15	G7 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa	PSEUDOMONAS AERUGINOSA	2	X-RAY DIFFRACTION	98.5
4CYR	HYDROLASE	04/14/14	G4 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa	PSEUDOMONAS AERUGINOSA	1.72	X-RAY DIFFRACTION	98.7
4CXK	HYDROLASE	04/07/14	G9 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa	PSEUDOMONAS AERUGINOSA	1.86	X-RAY DIFFRACTION	98.1
4CYS	HYDROLASE	04/14/14	G6 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa, in complex with Phenylphosphonic acid	PSEUDOMONAS AERUGINOSA	1.88	X-RAY DIFFRACTION	98.7
4CXS	HYDROLASE	04/08/14	G4 mutant of PAS, arylsulfatase from Pseudomonas aeruginosa, in complex with Phenylphosphonic acid	PSEUDOMONAS AERUGINOSA	2.3	X-RAY DIFFRACTION	98.7

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name	Source Accession	Source DB	Version	Target Accession	Target Description	Percent Identity	Alignment Length	E-Value
2-Aminopropanedioic Acid	DB02289	DrugBank	5.1.4	P51691	Arylsulfatase	100.0	536	0.0e+00

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000181 (366 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2G_04100 Search term: arylsulfatase

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000264914 arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714] E-value: 3.4e-30 Percent Identity: 29.9
Ensembl 110, assembly GRCh38.p14	ENSP00000456339 arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714] E-value: 3.4e-30 Percent Identity: 29.9
Ensembl 110, assembly GRCh38.p14	ENSP00000379455 arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714] E-value: 3.4e-30 Percent Identity: 29.9

References