Pseudomonas aeruginosa PACS2, A0K_RS00935

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa PACS2
GCF_000168335.1|latest
Locus Tag
A0K_RS00935
Name
Replicon chromosome
Genomic location 205969 - 207579 (- strand)

Cross-References

RefSeq ZP_01363090.1
GI 107099172
NCBI Locus Tag A0K_RS00935

Product

Feature Type CDS
Coding Frame 1
Product Name
arylsulfatase
Synonyms
Evidence for Translation
Charge (pH 7) -12.39
Kyte-Doolittle Hydrophobicity Value -0.378
Molecular Weight (kDa) 59.9
Isoelectric Point (pI) 5.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4CYS HYDROLASE 04/14/14 G6 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa, in complex with Phenylphosphonic acid PSEUDOMONAS AERUGINOSA 1.88 X-RAY DIFFRACTION 98.7
4CXS HYDROLASE 04/08/14 G4 mutant of PAS, arylsulfatase from Pseudomonas aeruginosa, in complex with Phenylphosphonic acid PSEUDOMONAS AERUGINOSA 2.3 X-RAY DIFFRACTION 98.7
1HDH HYDROLASE 11/16/00 Arylsulfatase from Pseudomonas aeruginosa Pseudomonas aeruginosa 1.3 X-RAY DIFFRACTION 99.8
4CXU HYDROLASE 04/08/14 G4 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa, in complex with 3-Br-Phenolphenylphosphonate PSEUDOMONAS AERUGINOSA 2.03 X-RAY DIFFRACTION 98.7
4CXK HYDROLASE 04/07/14 G9 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa PSEUDOMONAS AERUGINOSA 1.86 X-RAY DIFFRACTION 98.1
5AJ9 HYDROLASE 02/20/15 G7 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa PSEUDOMONAS AERUGINOSA 2 X-RAY DIFFRACTION 98.5
4CYR HYDROLASE 04/14/14 G4 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa PSEUDOMONAS AERUGINOSA 1.72 X-RAY DIFFRACTION 98.7

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
2-Aminopropanedioic Acid DB02289 DrugBank 5.1.4 P51691 Arylsulfatase 100.0 536 0.0e+00

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000181 (366 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: A0K_RS00935
Search term: arylsulfatase

Human Homologs

Ensembl 110, assembly GRCh38.p14
arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714]
E-value: 3.4e-30
Percent Identity: 29.9
Ensembl 110, assembly GRCh38.p14
arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714]
E-value: 3.4e-30
Percent Identity: 29.9
Ensembl 110, assembly GRCh38.p14
arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714]
E-value: 3.4e-30
Percent Identity: 29.9

References

No references are associated with this feature.