Pseudomonas aeruginosa PACS2, A0K_RS05475 (murD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa PACS2
GCF_000168335.1|latest
Locus Tag
A0K_RS05475
Name
murD
Replicon chromosome
Genomic location 1141206 - 1142552 (+ strand)

Cross-References

RefSeq ZP_01363919.1
GI 107100001
NCBI Locus Tag A0K_RS05475

Product

Feature Type CDS
Coding Frame 1
Product Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Synonyms
Evidence for Translation
Charge (pH 7) -6.27
Kyte-Doolittle Hydrophobicity Value 0.130
Molecular Weight (kDa) 48.1
Isoelectric Point (pI) 5.70

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
8DP2 LIGASE 07/14/22 Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 in complex with UMA (Uridine-5'-diphosphate-N-acetylmuramoyl-L-Alanine) Pseudomonas aeruginosa PAO1 1.6 X-RAY DIFFRACTION 99.5
7SY9 LIGASE 11/24/21 Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.75 X-RAY DIFFRACTION 99.5
7U35 LIGASE 02/25/22 Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 in complex with ADP Pseudomonas aeruginosa PAO1 1.95 X-RAY DIFFRACTION 99.5

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004004 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: A0K_RS05475
Search term: murD

Human Homologs

References

No references are associated with this feature.