Pseudomonas aeruginosa PACS2, A0K_RS21965

Cytoplasmic Membrane
Outer Membrane

Gene Feature Overview

Strain Pseudomonas aeruginosa PACS2
Locus Tag
Replicon chromosome
Genomic location 4687622 - 4688260 (+ strand)


RefSeq ZP_01367005.1
GI 107103087
NCBI Locus Tag A0K_RS21965


Feature Type CDS
Coding Frame 1
Product Name
TetR family transcriptional regulator
Evidence for Translation
Charge (pH 7) -2.70
Kyte-Doolittle Hydrophobicity Value -0.400
Molecular Weight (kDa) 24.5
Isoelectric Point (pI) 6.25

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
nalD NalD is a repressor of MexAB-OprM. Mutations lead to multidrug resistance and MexAB-OprM overexpression. [PMID:15855496] ARO:3000819 protein overexpression model Strict 429.5 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5DAJ TRANSCRIPTION REGULATOR 08/20/15 Crystal structure of NalD, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 2.65 X-RAY DIFFRACTION 100.0
5H9T TRANSCRIPTION REGULATOR 12/29/15 Crystal structure of native NalD at resolution of 2.9, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 2.89 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002095 (523 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: A0K_RS21965

Human Homologs


No references are associated with this feature.