Pseudomonas aeruginosa PAO1, PA0551 (epd)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0551
Name
epd
Synonym: gapB
Replicon chromosome
Genomic location 610214 - 611275 (+ strand)
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249242.1
GI 15595748
Affymetrix PA0551_epd_at
DNASU PaCD00006238
Entrez 879410
GenBank AAG03940.1
INSDC AAG03940.1
NCBI Locus Tag PA0551
protein_id(GenBank) gb|AAG03940.1|AE004491_7|gnl|PseudoCAP|PA0551
TIGR NTL03PA00552
UniParc UPI00000C50AE
UniProtKB Acc Q9I5Y5
UniProtKB ID Q9I5Y5_PSEAE
UniRef100 UniRef100_W0YM42
UniRef50 UniRef50_Q3ILL8
UniRef90 UniRef90_A6UZ14

Product

Feature Type CDS
Coding Frame 1
Product Name
D-erythrose 4-phosphate dehydrogenase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.80
Kyte-Doolittle Hydrophobicity Value -0.174
Molecular Weight (kDa) 38.7
Isoelectric Point (pI) 5.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 607 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000535 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0551
Search term: epd

Human Homologs

Ensembl 110, assembly GRCh38.p14
glyceraldehyde-3-phosphate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4141]
E-value: 3.8e-62
Percent Identity: 37.1
Ensembl 110, assembly GRCh38.p14
glyceraldehyde-3-phosphate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4141]
E-value: 3.8e-62
Percent Identity: 37.1
Ensembl 110, assembly GRCh38.p14
glyceraldehyde-3-phosphate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4141]
E-value: 3.8e-62
Percent Identity: 37.1

References

Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'-phosphate biosynthesis.
Zhao G, Pease AJ, Bharani N, Winkler ME
J Bacteriol 1995 May;177(10):2804-12
PubMed ID: 7751290
Comparative enzymatic properties of GapB-encoded erythrose-4-phosphate dehydrogenase of Escherichia coli and phosphorylating glyceraldehyde-3-phosphate dehydrogenase.
Boschi-Muller S, Azza S, Pollastro D, Corbier C, Branlant G
J Biol Chem 1997 Jun 13;272(24):15106-12
PubMed ID: 9182530