Pseudomonas aeruginosa PAO1, PA0872 (phhA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0872
Name
phhA
Replicon chromosome
Genomic location 952619 - 953407 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249563.1
GI 15596069
Affymetrix PA0872_phhA_at
DNASU PaCD00006401
Entrez 879709
GenBank AAG04261.1
INSDC AAG04261.1
NCBI Locus Tag PA0872
protein_id(GenBank) gb|AAG04261.1|AE004522_3|gnl|PseudoCAP|PA0872
TIGR NTL03PA00873
UniParc UPI00001318A1
UniProtKB Acc P43334
UniProtKB ID PH4H_PSEAE
UniRef100 UniRef100_P43334
UniRef50 UniRef50_P43334
UniRef90 UniRef90_P43334

Product

Feature Type CDS
Coding Frame 1
Product Name
phenylalanine-4-hydroxylase
Product Name Confidence: Class 1
Synonyms phenylalanine 4-monooxygenase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.90
Kyte-Doolittle Hydrophobicity Value -0.224
Molecular Weight (kDa) 30.3
Isoelectric Point (pI) 5.57

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 124 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000839 (523 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0872
Search term: phhA

Human Homologs

References

Pseudomonas aeruginosa possesses homologues of mammalian phenylalanine hydroxylase and 4 alpha-carbinolamine dehydratase/DCoH as part of a three-component gene cluster.
Zhao G, Xia T, Song J, Jensen RA
Proc Natl Acad Sci U S A 1994 Feb 15;91(4):1366-70
PubMed ID: 8108417