Pseudomonas aeruginosa PAO1, PA1155 (nrdB)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
Locus Tag
Replicon chromosome
Genomic location 1249907 - 1251154 (- strand)


RefSeq NP_249846.1
GI 15596352
Affymetrix PA1155_nrdB_at
Entrez 877692
GenBank AAG04544.1
INSDC AAG04544.1
NCBI Locus Tag PA1155
protein_id(GenBank) gb|AAG04544.1|AE004545_7|gnl|PseudoCAP|PA1155
UniParc UPI00000C5279
UniProtKB Acc Q9I4I2
UniRef100 UniRef100_Q9I4I2
UniRef50 UniRef50_Q9I4I2
UniRef90 UniRef90_Q9I4I2


Feature Type CDS
Coding Frame 1
Product Name
NrdB, tyrosyl radical-harboring component of class Ia ribonucleotide reductase
Product Name Confidence: Class 1
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -21.44
Kyte-Doolittle Hydrophobicity Value -0.431
Molecular Weight (kDa) 47.4
Isoelectric Point (pI) 4.50

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 403 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001114 (536 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA1155
Search term: nrdB

Human Homologs

Ensembl 110, assembly GRCh38.p14
ribonucleotide reductase regulatory TP53 inducible subunit M2B [Source:HGNC Symbol;Acc:HGNC:17296]
E-value: 7.9e-35
Percent Identity: 26.5


Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Ribonucleotide reductase modularity: Atypical duplication of the ATP-cone domain in Pseudomonas aeruginosa.
Torrents E, Westman M, Sahlin M, Sjöberg BM
J Biol Chem 2006 Sep 1;281(35):25287-96
PubMed ID: 16829681
Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability.
Elledge SJ, Davis RW
Mol Cell Biol 1987 Aug;7(8):2783-93
PubMed ID: 3313004
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994