Pseudomonas aeruginosa PAO1, PA1273 (cobB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA1273
Name
cobB
Synonym: cbiA
Replicon chromosome
Genomic location 1384361 - 1385668 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249964.1
GI 15596470
Affymetrix PA1273_cobB_at
Entrez 881727
GenBank AAG04662.1
INSDC AAG04662.1
NCBI Locus Tag PA1273
protein_id(GenBank) gb|AAG04662.1|AE004557_3|gnl|PseudoCAP|PA1273
TIGR NTL03PA01274
UniParc UPI0000127DCB
UniProtKB Acc Q9I471
UniProtKB ID COBB_PSEAE
UniRef100 UniRef100_Q9I471
UniRef50 UniRef50_Q9I471
UniRef90 UniRef90_Q9I471

Product

Feature Type CDS
Coding Frame 1
Product Name
cobyrinic acid a,c-diamide synthase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.55
Kyte-Doolittle Hydrophobicity Value 0.042
Molecular Weight (kDa) 46.5
Isoelectric Point (pI) 6.29

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 353 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001220 (548 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1273
Search term: cobB

Human Homologs

References

Nucleotide sequence of a Pseudomonas denitrificans 5.4-kilobase DNA fragment containing five cob genes and identification of structural genes encoding S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase and cobyrinic acid a,c-diamide synthase.
Crouzet J, Cauchois L, Blanche F, Debussche L, Thibaut D, Rouyez MC, Rigault S, Mayaux JF, Cameron B
J Bacteriol 1990 Oct;172(10):5968-79
PubMed ID: 2211520