Pseudomonas aeruginosa PAO1, PA1515 (alc)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1515
Name
alc
Replicon chromosome
Genomic location 1647101 - 1648099 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250206.1
GI 15596712
Affymetrix PA1515_alc_at
DNASU PaCD00006694
Entrez 883130
GenBank AAG04904.1
INSDC AAG04904.1
NCBI Locus Tag PA1515
protein_id(GenBank) gb|AAG04904.1|AE004580_4|gnl|PseudoCAP|PA1515
TIGR NTL03PA01516
UniParc UPI00000C53BA
UniProtKB Acc Q9I3J8
UniProtKB ID ALLC_PSEAE
UniRef100 UniRef100_Q9I3J8
UniRef50 UniRef50_Q9I3J8
UniRef90 UniRef90_Q9I3J8

Product

Feature Type CDS
Coding Frame 1
Product Name
allantoicase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -6.27
Kyte-Doolittle Hydrophobicity Value -0.444
Molecular Weight (kDa) 36.8
Isoelectric Point (pI) 6.30

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 48 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003842 (460 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1515
Search term: alc
Search term: allantoicase

Human Homologs

Ensembl 110, assembly GRCh38.p14
allantoicase [Source:HGNC Symbol;Acc:HGNC:17377]
E-value: 1.9e-68
Percent Identity: 36.5

References

Allantoinase and allantoicase synthesis in Pseudomonas aerguinosa.
Rijnierse VF, Van Der Drift C, Vogels GD
Can J Microbiol 1977 May;23(5):633-7
PubMed ID: 406022
Nucleotide sequence and DNA recognition elements of alc, the structural gene which encodes allantoicase, a purine catabolic enzyme of Neurospora crassa.
Lee H, Fu YH, Marzluf GA
Biochemistry 1990 Sep 18;29(37):8779-87
PubMed ID: 2148685