Pseudomonas aeruginosa PAO1, PA1666 (lip2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1666
Name
lip2
Replicon chromosome
Genomic location 1816352 - 1816858 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250357.1
GI 15596863
Affymetrix PA1666_at
DNASU PaCD00006754
Entrez 882020
GenBank AAG05055.1
INSDC AAG05055.1
NCBI Locus Tag PA1666
protein_id(GenBank) gb|AAG05055.1|AE004594_7|gnl|PseudoCAP|PA1666
TIGR NTL03PA01667
UniParc UPI00000C5438
UniProtKB Acc Q9I359
UniProtKB ID Q9I359_PSEAE
UniRef100 UniRef100_Q9I359
UniRef50 UniRef50_Q9I359
UniRef90 UniRef90_Q9I359

Product

Feature Type CDS
Coding Frame 1
Product Name
Lip2
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 0.21
Kyte-Doolittle Hydrophobicity Value -0.106
Molecular Weight (kDa) 18.4
Isoelectric Point (pI) 7.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category Hcp secretion island-2 encoded type VI secretion system (H2-T6SS)
Evidence ECO:0000317
genomic context evidence used in manual assertion
Host Organism Homo sapiens
Notes H2-T6SS rendered inactive via clpV2 deletion.
Reference 22665491

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 80 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000079 (812 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1666
Search term: lip2
Search term: Lip2

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295